9001cc金沙首页(以诚为本)Official website /tag/鑲跨槫/ 鍏ㄦ柟浣嶇殑鍒嗗瓙妫€娴嬨€佸垱鏂板尰鑽€佸尰鐤楁湇鍔?鍋ュ悍涔愬湡锛岀浣戜紬鐢烖/description> Fri, 01 Apr 2022 03:07:53 +0000 zh-CN hourly 1 https://wordpress.org/?v=6.1.7 涔愬湡鍔╁姏涓村簥鍙傛暟涓庤偪鐦ょ獊鍙樿礋鑽稵MB鐩稿叧鎬х爺绌迭/title> <link>/2022/03/%e4%b9%90%e5%9c%9f%e5%8a%a9%e5%8a%9b%e4%b8%b4%e5%ba%8a%e5%8f%82%e6%95%b0%e4%b8%8e%e8%82%bf%e7%98%a4%e7%aa%81%e5%8f%98%e8%b4%9f%e8%8d%b7tmb%e7%9b%b8%e5%85%b3%e6%80%a7%e7%a0%94%e7%a9%b6/</link> <dc:creator><![CDATA[CLB]]></dc:creator> <pubDate>Thu, 17 Mar 2022 02:14:25 +0000</pubDate> <category><![CDATA[鏂伴椈]]></category> <category><![CDATA[棣栭〉鏂囩珷]]></category> <category><![CDATA[TMB]]></category> <category><![CDATA[涔愬湡鍖诲妫€楠宂]></category> <category><![CDATA[鑲跨槫]]></category> <guid isPermaLink="false">/?p=8775</guid> <description><![CDATA[<p>涔愬湡鍖诲妫€楠屼笌姹熻タ鐪佽偪鐦ゅ尰闄笓瀹跺悎浣滃彂琛ㄨ鏂嘃/p> <p>The post <a rel="nofollow" href="/2022/03/%e4%b9%90%e5%9c%9f%e5%8a%a9%e5%8a%9b%e4%b8%b4%e5%ba%8a%e5%8f%82%e6%95%b0%e4%b8%8e%e8%82%bf%e7%98%a4%e7%aa%81%e5%8f%98%e8%b4%9f%e8%8d%b7tmb%e7%9b%b8%e5%85%b3%e6%80%a7%e7%a0%94%e7%a9%b6/">涔愬湡鍔╁姏涓村簥鍙傛暟涓庤偪鐦ょ獊鍙樿礋鑽稵MB鐩稿叧鎬х爺绌迭/a> appeared first on <a rel="nofollow" href="">涔愬湡鐢熷懡绉戞妧</a>.</p> ]]></description> <content:encoded><![CDATA[<blockquote><p>杩戞棩锛屼箰鍦熷尰瀛︽楠屼笌姹熻タ鐪佽偪鐦ゅ尰闄笓瀹跺悎浣滃彂琛ㄨ鏂団€淐linical and molecular impacts of tumor mutational burden in histological and cytological specimens from cancer patients鈥濅簬<em>Annals of Translational Medicine</em>鏈熷垔涓婏紝涔愬湡浣滀负骞跺垪閫氳鍜屽苟鍒楃涓€浣滆€呮繁搴﹀弬涓庤椤圭爺绌躲€侟/p></blockquote> <section> <section> <h4><strong>鏂囩珷瀵艰</strong></h4> <section data-width="100%"></section> </section> </section> <p>鑲跨槫绐佸彉璐熻嵎(TMB)鏄瘎浼板厤鐤鏌ョ偣鎶戝埗鍓?ICI)鐤楁晥鐨勬湁鏁堢敓鐗╂爣蹇楃墿涔嬩竴锛岀劧鑰岋紝瀹冧笌涓村簥鍙傛暟闂寸殑鍏崇郴灏氭湭琚厖鍒嗘帰璁ㄣ€備箰鍦熷尰瀛︽楠屼笌姹熻タ鐪佽偪鐦ゅ尰闄㈠悎浣滐紝閫氳繃娴嬪簭鍒嗘瀽1504渚嬭偪鐦ょ粍缁囨牱鏈拰496渚嬭娑叉牱鏈潵鎺㈣TMB涓庡勾榫勩€佽偪鐦ょ被鍨嬪拰鍩哄洜绐佸彉涔嬮棿鐨勫叧绯汇€侟/p> <section></section> <section> <section> <h4><strong>鐮旂┒鍙戠幇</strong></h4> <section data-width="100%"></section> </section> </section> <p>1锛夊浜庤娑叉牱鏈紝涓庡勾榫勨墹56宀佹垨骞撮緞鍦?6宀亊68宀佺殑鎮ｈ€呯浉姣旓紝骞撮緞鈮?8宀佺殑鎮ｈ€匱MB鏄庢樉鍗囬珮銆傛惡甯RAS p.G12绐佸彉涓嶬RAS鍏朵粬鍙樺紓鎮ｈ€呯殑TMB鍏锋湁鏄捐憲宸紓銆侟/p> <p>2锛夊浜庣粍缁囨牱鏈紝TMB鍦ㄥ勾榫?3宀亊65宀佷箣闂磋〃杈捐緝楂橈紝鍦ㄥ勾榫勨墺65宀佷汉缇や腑杈冧綆銆俆MB鍦ㄨ偤鑵洪碁鐧?ASC)銆佽偤鑵虹檶(LUAD)銆佽偤槌炵姸缁嗚優鐧?LUSC)銆侀潪灏忕粏鑳炶偤鐧?NSCLC)鍜屽皬缁嗚優鑲虹檶(SCLC)绛変笉鍚岀殑鑲跨槫缁勭粐绫诲瀷闂村瓨鍦ㄦ樉钁楀樊寮傘€俆MB楂樹綆涓嶬RAS p.G12A銆乸.G12C銆乸.G12D銆乸.G12R銆乸.G12S銆乸.G12V绛塊RAS绐佸彉鐩稿叧銆侟/p> <section> <section> <section>3锛夋棤璁哄湪缁勭粐鏍锋湰杩樻槸琛€娑叉牱鏈腑锛孴MB鍜孧SI鍊兼棤绾挎€х浉鍏炽€侟/section> </section> </section> <section> <section data-support="96缂栬緫鍣? data-style-id="32613"> <section></section> </section> <section> <section> <h4><strong>鎬荤粨</strong></h4> <section data-width="100%"></section> </section> </section> <p>TMB鍙兘涓庡勾榫勩€佽偪鐦ょ被鍨嬩互鍙奒RAS绐佸彉鐩稿叧銆備綔涓哄厤鐤鏌ョ偣鎶戝埗鍓傜殑涓€涓綔鍦ㄧ敓鐗╂爣蹇楃墿锛屽垎鏋愬勾榫勩€佽偪鐦ょ被鍨嬪拰KRAS绐佸彉鍙兘涓篢MB鐨勮瘎浼版彁渚涙洿鏈夌泭鐨勫府鍔┿€侟/p> </section> <section> <section> <section></section> <section data-support="96缂栬緫鍣? data-style-id="32676"> <section> <section data-width="100%"> <h3><strong>鏂囩珷鍏蜂綋瑙ｈ</strong></h3> </section> </section> <section> <section> <section data-support="96缂栬緫鍣? data-style-id="32577"> <section> <section> <section> <section></section> <section> <h5><strong>鏂规硶</strong></h5> </section> </section> </section> </section> </section> <p>鏈爺绌跺叡绾冲叆浜?019鍒?021骞撮棿涔愬湡涓庢睙瑗跨渷鑲跨槫鍖婚櫌鍚堜綔妫€娴嬬殑496渚嬭娑插拰1504渚嬭偪鐦ょ粍缁囨牱鏈紝閫氳繃鍩哄洜妫€娴嬪強缁熻瀛﹀垎鏋愭帰璁═MB涓庝复搴婃牱鏈勾榫勩€佽偪鐦ょ被鍨嬪拰鍩哄洜绐佸彉锛圞RAS鍜孍GFR锛変箣闂寸殑鍏崇郴銆侟/p> <p>鏂囩珷鎵€鏈夌爺绌跺潎绗﹀悎璧皵杈涘熀瀹ｈ█锛?013骞翠慨璁級锛屽苟閫氳繃浜嗘睙瑗跨渷鑲跨槫鍖婚櫌浼︾悊濮斿憳浼氭壒鍑嗭紙缂栧彿锛?021ky229锛夛紝鎵€鏈夋偅鑰呭潎绛剧讲浜嗙煡鎯呭悓鎰忎功銆侟/p> <section> <section> <section> <section></section> <section> <h5><strong>鍒嗘瀽缁撴灉/鏍锋湰鐗瑰緛</strong></h5> </section> </section> </section> </section> <p>鐮旂┒鍏辩撼鍏?96渚嬭娑叉牱鏈拰1504渚嬬粍缁囨牱鏈紝琛€娑叉牱鏈殑骞撮緞鑼冨洿涓猴紙61.58 卤12.48锛夊瞾锛岀敺:濂昌314:182锛涚粍缁囨牱鏈殑骞撮緞鑼冨洿涓猴紙57.42卤14.67锛夊瞾锛岀敺:濂昌866:638銆傛牱鏈殑鍏蜂綋淇℃伅瑙佽〃1銆侟/p> <p>Table 1 Characteristics of blood samples and tissue samples</p> <p><img decoding="async" class="aligncenter size-full wp-image-8819" src="/wp-content/uploads/2022/04/1.png" alt="" width="440" height="737" srcset="/wp-content/uploads/2022/04/1.png 440w, /wp-content/uploads/2022/04/1-179x300.png 179w, /wp-content/uploads/2022/04/1-421x705.png 421w" sizes="(max-width: 440px) 100vw, 440px" /></p> <p><img decoding="async" class="aligncenter size-full wp-image-8821" src="/wp-content/uploads/2022/04/2.png" alt="" width="439" height="343" srcset="/wp-content/uploads/2022/04/2.png 439w, /wp-content/uploads/2022/04/2-300x234.png 300w" sizes="(max-width: 439px) 100vw, 439px" /></p> <p> </p> <section> <section> <section> <section></section> <section> <h5><strong>TMB涓庡勾榫勩€佽偪鐦ょ被鍨嬪強鍩哄洜绐佸彉鐨勫叧绯狐/strong></h5> </section> </section> </section> </section> <p>鍦?96渚嬭娑叉牱鏈腑锛孴MB鍊煎湪骞撮緞鈮?6宀佸拰骞撮緞鍦?6宀佸埌68宀佷箣闂寸殑浜虹兢涓病鏈夋樉钁楀樊寮傦紝鑰屽湪骞撮緞鈮?8宀佺殑浜虹兢涓樉钁楀崌楂橈紙鍥?A锛孭<0.05锛孠ruskal-Wallis锛夈€傚叾涓?2渚嬩负MSI-H锛?84渚嬩负MSS/MSI-L锛堝浘1B锛夈€傚鍥?C鎵€绀猴紝鍒嗘瀽缁撴灉琛ㄦ槑MSI鐨勬瘮鍊硷紙%锛変笌TMB娌℃湁绾挎€х浉鍏虫€э紙R=鈭?.093, P=0.038锛夈€侟/p> <p>閫氳繃璇勪及鑲跨槫绫诲瀷鍜孴MB鐨勫叧绯诲彂鐜帮紝TMB鍜岃偪鐦ょ被鍨嬫棤鍏筹紝鍦ㄨ偤鑵洪碁鐧屻€佽偤鑵虹檶銆佽偤槌炵檶銆侀潪灏忕粏鑳炶偤鐧屽拰灏忕粏鑳炶偤鐧屼腑TMB鏃犲樊寮傦紙鍥?D锛孭=0.33, Kruskal-Wallis锛夈€侟/p> <div id="attachment_8823" style="width: 1090px" class="wp-caption aligncenter"><img aria-describedby="caption-attachment-8823" decoding="async" class="wp-image-8823 size-full" src="/wp-content/uploads/2022/04/3.png" alt="" width="1080" height="670" srcset="/wp-content/uploads/2022/04/3.png 1080w, /wp-content/uploads/2022/04/3-300x186.png 300w, /wp-content/uploads/2022/04/3-1030x639.png 1030w, /wp-content/uploads/2022/04/3-768x476.png 768w, /wp-content/uploads/2022/04/3-705x437.png 705w" sizes="(max-width: 1080px) 100vw, 1080px" /><p id="caption-attachment-8823" class="wp-caption-text">鍥?-琛€娑叉牱鏈腑TMB涓庡勾榫勩€丮SI鎴栬偪鐦ょ被鍨嬩箣闂寸殑鍏崇郴</p></div> <p><strong>A.聽</strong>TMB鍦ㄥ勾榫勨墹56宀侊紙n=157锛夛紝骞撮緞56-68宀侊紙n=177锛夊拰骞撮緞鈮?8宀侊紙n=161锛変箣闂寸殑琛ㄨ揪宸紓銆侟/p> <p><strong>B&C.聽</strong>MSI-H锛坣=12锛夊拰MSS/MSI-L锛坣=484锛夌殑鎯呭喌鍙婅娑叉牱鏈腑MSI姣斿€间笌TMB鐨勫叧绯汇€侟/p> <p><strong>D.聽</strong>鑲鸿吅槌炵檶锛坣=0锛夈€佽偤鑵虹檶锛坣=131锛夈€佽偤槌炵檶锛坣=7锛夈€侀潪灏忕粏鑳炶偤鐧岋紙n=3锛夊拰灏忕粏鑳炶偤鐧岋紙n=3锛夋牱鏈腑鐨凾MB鎯呭喌銆侟/p> <p>鍦?390渚嬬粍缁囨牱鏈腑锛屽鍥?鎵€绀猴紝涓庡勾榫勨墹53宀佷汉缇ょ浉姣旓紝TMB鍊煎湪骞撮緞鈮?5宀佸拰骞撮緞鍦?3宀佸埌65宀佷箣闂寸殑浜虹兢涓病鏈夋樉钁楀樊寮傦紝鍦?3宀佸埌65宀佷汉缇や腑TMB鏄捐憲鍗囬珮锛屽湪鈮?5宀佷汉缇や腑TMB鏄捐憲闄嶄綆锛堝浘2A锛孭<0.05, Kruskal-Wallis锛夈€傚叾涓?3渚嬩负MSI-H锛?357渚嬩负MSS/MSI-L锛堝浘2B锛夈€傚鍥?C鎵€绀猴紝杩欎簺缁撴灉琛ㄦ槑MSI鐨勬瘮鍊硷紙%锛変笌TMB娌℃湁绾挎€х浉鍏虫€э紙R=0.29, P<2.2e-16锛夈€侟/p> <p>閫氳繃璇勪及鑲跨槫绫诲瀷鍜孴MB鐨勫叧绯诲彂鐜帮紝TMB涓庤偪鐦ょ被鍨嬬浉鍏筹紙鍥?D, P=0.037, Kruskal-Wallis锛夛紝鍦ㄨ偤鑵洪碁鐧屻€佽偤鑵虹檶銆佽偤槌炵檶銆侀潪灏忕粏鑳炶偤鐧屽拰灏忕粏鑳炶偤鐧岄棿瀛樺湪宸紓銆傝€屼笖TMB鍦ㄧ粨鐩磋偁鐧岀殑琛€娑叉牱鏈拰缁勭粐鏍锋湰涓潎瀛樺湪宸紓锛堝浘2E锛孭=0.036, Wilcoxon锛夈€侟/p> <div id="attachment_8825" style="width: 1090px" class="wp-caption aligncenter"><img aria-describedby="caption-attachment-8825" decoding="async" class="wp-image-8825 size-full" src="/wp-content/uploads/2022/04/4.png" alt="" width="1080" height="485" srcset="/wp-content/uploads/2022/04/4.png 1080w, /wp-content/uploads/2022/04/4-300x135.png 300w, /wp-content/uploads/2022/04/4-1030x463.png 1030w, /wp-content/uploads/2022/04/4-768x345.png 768w, /wp-content/uploads/2022/04/4-705x317.png 705w" sizes="(max-width: 1080px) 100vw, 1080px" /><p id="caption-attachment-8825" class="wp-caption-text">鍥?-缁勭粐鏍锋湰涓璗MB涓庡勾榫勩€丮SI鎴栬偪鐦ょ被鍨嬩箣闂寸殑鍏崇郴</p></div> <p><strong>A.聽</strong>TMB鍦ㄥ勾榫勨墹53宀侊紙n=489锛夛紝骞撮緞53-65宀侊紙n=497锛夊拰骞撮緞鈮?5宀侊紙n=512锛変箣闂寸殑琛ㄨ揪宸紓銆侟/p> <p><strong>B&C.聽</strong>MSI-H锛坣=33锛夊拰MSS/MSI-L锛坣=1357锛夌殑鎯呭喌鍙婄粍缁囨牱鏈腑MSI姣斿€间笌TMB鐨勫叧绯汇€侟/p> <p><strong>D.聽</strong>鑲鸿吅槌炵檶锛坣=1锛夈€佽偤鑵虹檶锛坣=222锛夈€佽偤槌炵檶锛坣=26锛夈€侀潪灏忕粏鑳炶偤鐧岋紙n=3锛夊拰灏忕粏鑳炶偤鐧岋紙n=8锛夋牱鏈腑TMB琛ㄨ揪鎯呭喌銆侟/p> <p>E. TMB鍦ㄧ粨鐩磋偁鐧岃娑叉牱鏈紙n=4锛夊拰缁勭粐鏍锋湰锛坣=20锛変腑鐨勮〃杈炬儏鍐点€侟/p> <p>鍩哄洜绐佸彉鐘舵€佷笌TMB鐩稿叧銆傛棦寰€閮ㄥ垎鐮旂┒琛ㄦ槑锛屾惡甯GFR鍩哄洜绐佸彉鐨凬SCLC鎮ｈ€呭線寰€鍏锋湁杈冧綆鐨凾MB锛岃€孠RAS涓庤緝楂樼殑TMB鐩稿叧銆侟/p> <p>鍦ㄦ垜浠殑鐮旂┒涓紝琛€娑叉牱鏈腑鐨凨ruskal-Wallis鍒嗘瀽缁撴灉琛ㄦ槑锛孠RAS p.G12A銆乸.G12C銆乸.G12D銆乸.G12R銆乸.G12V鍜孠RAS鍏朵粬绐佸彉涔嬮棿鐨凾MB娌℃湁鏄捐憲宸紓锛圥=0.17锛夛紙鍥?A锛孭=0.17, Kruskal-Wallis锛夛紝浣嗘牴鎹甒ilcoxon 妫€楠岋紝KRAS鍏朵粬绐佸彉鍜孠RAS p.G12绐佸彉涔嬮棿鐨凾MB琛ㄨ揪瀛樺湪鏄捐憲宸紓锛圥=0.013锛屽浘3B锛夈€侟/p> <section>閫氳繃璇勪及EGFR绐佸彉涓嶵MB鐨勫叧绯伙紝鍙戠幇EGFR绐佸彉闃存€ф偅鑰咃紙n=484锛変笌EGFR绐佸彉闃虫€ф偅鑰咃紙n=12锛夌殑TMB鏃犳樉钁楁€у樊寮傦紙鍥?C锛孭=0.11锛學ilcoxon锛夛紝EGFR T790M绐佸彉闃存€у拰闃虫€ф偅鑰呬箣闂寸殑TMB涔熶笉瀛樺湪缁熻瀛﹀樊寮傦紙鍥 3D锛夈€侟/section> <div id="attachment_8828" style="width: 1090px" class="wp-caption aligncenter"><img aria-describedby="caption-attachment-8828" decoding="async" class="wp-image-8828 size-full" src="/wp-content/uploads/2022/04/5.png" alt="" width="1080" height="745" srcset="/wp-content/uploads/2022/04/5.png 1080w, /wp-content/uploads/2022/04/5-300x207.png 300w, /wp-content/uploads/2022/04/5-1030x711.png 1030w, /wp-content/uploads/2022/04/5-768x530.png 768w, /wp-content/uploads/2022/04/5-705x486.png 705w" sizes="(max-width: 1080px) 100vw, 1080px" /><p id="caption-attachment-8828" class="wp-caption-text">鍥?-琛€娑叉牱鏈腑TMB鍜岀檶鐥囩浉鍏冲熀鍥犵獊鍙樼殑鍏崇郴</p></div> <section> <section> <section><strong>A.聽</strong>TMB鍦↘RAS p.G12A (n=1), p.G12C (n=3), p.G12D (n=9), p.G12R (n=5), p.G12V (n=11),鍜孠RAS鍏朵粬绐佸彉 (n=467)涓殑琛ㄨ揪鎯呭喌銆侟/section> <section><strong>B.聽</strong>TMB鍦↘RAS鍏朵粬绐佸彉锛坣=467锛夊拰KRAS p.G12锛坣=29锛変腑鐨勮〃杈炬儏鍐点€侟/section> <section><strong>C.聽</strong>TMB鍦‥GFR绐佸彉闃存€ф偅鑰 (n=484)鍜岀獊鍙橀槼鎬ф偅鑰 (n=12)涓殑琛ㄨ揪鎯呭喌銆侟/section> <section><strong>D.聽</strong>TMB鍦‥GFR T790M绐佸彉闃存€у拰绐佸彉闃虫€ф偅鑰呬箣闂寸殑琛ㄨ揪鎯呭喌銆侟/section> </section> </section> <section>鍦ㄧ粍缁囨牱鏈腑锛孠RAS p.G12A銆乸.G12C銆乸.G12D銆乸.G12R銆乸.G12S銆乸.G12V鍜 KRAS鍏朵粬绐佸彉鐨凾MB瀛樺湪鏄捐憲鎬у樊寮傦紙鍥?A锛孭=0.033锛孠ruskal-Wallis)锛孠RAS鍏朵粬绐佸彉鍜孠RAS p.G12绐佸彉涔嬮棿鐨凾MB涔熷瓨鍦ㄦ樉钁楁€у樊寮傦紙鍥?C锛孭=0.0051锛學ilcoxon锛夈€備絾EGFR绐佸彉闃存€ф偅鑰呭拰EGFR绐佸彉闃虫€ф偅鑰呬笌TMB鏈彂鐜扮浉鍏虫€э紙鍥?D锛孭=0.59锛學ilcoxon锛夈€侟/section> <section><img decoding="async" class="aligncenter size-full wp-image-8830" src="/wp-content/uploads/2022/04/6.png" alt="" width="1080" height="681" srcset="/wp-content/uploads/2022/04/6.png 1080w, /wp-content/uploads/2022/04/6-300x189.png 300w, /wp-content/uploads/2022/04/6-1030x649.png 1030w, /wp-content/uploads/2022/04/6-768x484.png 768w, /wp-content/uploads/2022/04/6-705x445.png 705w" sizes="(max-width: 1080px) 100vw, 1080px" /></section> <p> </p> <section> <section><strong>鍥?-缁勭粐鏍锋湰涓璗MB鍜岀檶鐥囩浉鍏冲熀鍥犵獊鍙樼殑鍏崇郴</strong></section> </section> <section> <section> <section><strong>A&B.聽</strong>TMB鍦↘RAS p.G12A (n=7), p.G12C (n=13), p.G12D (n=81), p.G12R(n=6), p.G12S(n=8), p.G12V(n=56), 鍜孠RAS鍏朵粬绐佸彉(n=1333)涓殑琛ㄨ揪鎯呭喌銆侟/p> <p><strong>C.聽</strong>TMB鍦↘RAS鍏朵粬绐佸彉锛坣=1333锛夊拰KRAS p.G12锛坣=171锛変腑鐨勮〃杈炬儏鍐点€侟/p> <section> <section data-support="96缂栬緫鍣? data-style-id="32676"> <section> <section> <section> <section> <section><strong>D.聽</strong>TMB鍦‥GFR绐佸彉闃存€ф偅鑰 (n=1497) 鍜 EGFR绐佸彉闃虫€ф偅鑰 (n=7)涓殑琛ㄨ揪鎯呭喌銆侟/p> </section> </section> </section> </section> </section> </section> </section> </section> </section> </section> </section> </section> </section> </section> </section> <p>The post <a rel="nofollow" href="/2022/03/%e4%b9%90%e5%9c%9f%e5%8a%a9%e5%8a%9b%e4%b8%b4%e5%ba%8a%e5%8f%82%e6%95%b0%e4%b8%8e%e8%82%bf%e7%98%a4%e7%aa%81%e5%8f%98%e8%b4%9f%e8%8d%b7tmb%e7%9b%b8%e5%85%b3%e6%80%a7%e7%a0%94%e7%a9%b6/">涔愬湡鍔╁姏涓村簥鍙傛暟涓庤偪鐦ょ獊鍙樿礋鑽稵MB鐩稿叧鎬х爺绌迭/a> appeared first on <a rel="nofollow" href="">涔愬湡鐢熷懡绉戞妧</a>.</p> ]]></content:encoded> </item> </channel> </rss>