{"id":4778,"date":"2020-07-31T00:11:09","date_gmt":"2020-07-30T16:11:09","guid":{"rendered":"http:\/\/clbiomed.cn\/?post_type=portfolio&p=4778"},"modified":"2020-08-03T01:24:25","modified_gmt":"2020-08-02T17:24:25","slug":"mdx-birth-abnormality","status":"publish","type":"portfolio","link":"https:\/\/clbiomed.com\/projects\/mdx-birth-abnormality\/","title":{"rendered":"\u51fa\u751f\u7f3a\u9677"},"content":{"rendered":"<div class='flex_column av-64jp0-719f2d0b1a68efc99089506a785ca3e8 av_one_third  avia-builder-el-0  el_before_av_two_third  avia-builder-el-first  first flex_column_div '     ><section  class='av_textblock_section av-5w37w-c08846df7bbabb9ae5e2090c3bc3fd8b'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>\u4e50\u571f\u51fa\u751f\u7f3a\u9677\u68c0\u6d4b<\/h3>\n<p>\u63d0\u4f9b\u9488\u5bf9\u4e09\u79cd\u60c5\u51b5\u7684\u68c0\u6d4b\u670d\u52a1\uff1a\u51fa\u751f\u7f3a\u9677\u3001\u7591\u96be\u75c5\u6216\u7f55\u89c1\u75c5\u3001\u5bb6\u65cf\u9057\u4f20\u75c5\u3002<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-6v05w-ee117da138dbc38869481e6a2215e0af\">\n#top .avia-gallery.av-6v05w-ee117da138dbc38869481e6a2215e0af .avia-gallery-thumb a{\nwidth:14.2857%;\n}\n<\/style>\n<div  class='avia-gallery av-6v05w-ee117da138dbc38869481e6a2215e0af avia_animate_when_visible  avia-builder-el-2  el_after_av_textblock  avia-builder-el-last  avia_lazyload avia-gallery-animate avia-gallery-1'  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><meta itemprop=\"contentURL\" content=\"https:\/\/clbiomed.com\/projects\/mdx-birth-abnormality\/\"><a class='avia-gallery-big fakeLightbox lightbox avia-gallery-big-crop-thumb ' href=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature.jpg\" data-srcset=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature.jpg 773w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature-300x233.jpg 300w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature-768x596.jpg 768w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature-705x547.jpg 705w\" data-sizes=\"(max-width: 773px) 100vw, 773px\"  data-onclick='1' title='\u51fa\u751f\u7f3a\u9677\u68c0\u6d4b' ><span class='avia-gallery-big-inner'  itemprop=\"thumbnailUrl\" ><img decoding=\"async\" class=\"wp-image-4779 avia-img-lazy-loading-not-4779\"  width=\"773\" height=\"600\" src=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature.jpg\" title='\u51fa\u751f\u7f3a\u9677\u68c0\u6d4b' alt='' srcset=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature.jpg 773w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature-300x233.jpg 300w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature-768x596.jpg 768w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature-705x547.jpg 705w\" sizes=\"(max-width: 773px) 100vw, 773px\" \/><\/span><\/a><div class='avia-gallery-thumb'><a href=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature.jpg\" data-srcset=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature.jpg 773w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature-300x233.jpg 300w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature-768x596.jpg 768w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature-705x547.jpg 705w\" data-sizes=\"(max-width: 773px) 100vw, 773px\" data-rel='gallery-1' data-prev-img='https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature.jpg' class='first_thumb lightbox ' data-onclick='1' title='\u51fa\u751f\u7f3a\u9677\u68c0\u6d4b'  itemprop=\"thumbnailUrl\"  ><img decoding=\"async\" class=\"wp-image-4779 avia-img-lazy-loading-not-4779\"   src=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature-495x400.jpg\" width=\"495\" height=\"400\"  title='\u51fa\u751f\u7f3a\u9677\u68c0\u6d4b' alt='' \/><div class='big-prev-fake'><img decoding=\"async\" class=\"wp-image-4779 avia-img-lazy-loading-not-4779\"  width=\"773\" height=\"600\" src=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature.jpg\" title='\u51fa\u751f\u7f3a\u9677\u68c0\u6d4b' alt='' srcset=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature.jpg 773w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature-300x233.jpg 300w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature-768x596.jpg 768w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/BrokenWing-feature-705x547.jpg 705w\" sizes=\"(max-width: 773px) 100vw, 773px\" \/><\/div><\/a><a href=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Chr-4-1030x460.jpg\" data-srcset=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Chr-4-1030x460.jpg 1030w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Chr-4-300x134.jpg 300w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Chr-4-768x343.jpg 768w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Chr-4-705x315.jpg 705w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Chr-4.jpg 1243w\" data-sizes=\"(max-width: 1030px) 100vw, 1030px\" data-rel='gallery-1' data-prev-img='https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Chr-4-845x555.jpg' class='lightbox ' data-onclick='2' title='\u51fa\u751f\u7f3a\u9677\u75c5\u4f8b'  itemprop=\"thumbnailUrl\"  ><img decoding=\"async\" class=\"wp-image-4787 avia-img-lazy-loading-not-4787\"   src=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Chr-4-495x400.jpg\" width=\"495\" height=\"400\"  title='\u51fa\u751f\u7f3a\u9677\u75c5\u4f8b' alt='' \/><div class='big-prev-fake'><img decoding=\"async\" class=\"wp-image-4787 avia-img-lazy-loading-not-4787\"  width=\"845\" height=\"555\" src=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Chr-4-845x555.jpg\" title='\u51fa\u751f\u7f3a\u9677\u75c5\u4f8b' alt='' \/><\/div><\/a><a href=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Repro-3-1.jpg\" data-srcset=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Repro-3-1.jpg 720w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Repro-3-1-300x183.jpg 300w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Repro-3-1-705x429.jpg 705w\" data-sizes=\"(max-width: 720px) 100vw, 720px\" data-rel='gallery-1' data-prev-img='https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Repro-3-1.jpg' class='lightbox ' data-onclick='3' title='\u51fa\u751f\u7f3a\u9677\u68c0\u6d4b'  itemprop=\"thumbnailUrl\"  ><img decoding=\"async\" class=\"wp-image-4789 avia-img-lazy-loading-not-4789\"   src=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Repro-3-1-495x400.jpg\" width=\"495\" height=\"400\"  title='\u51fa\u751f\u7f3a\u9677\u68c0\u6d4b' alt='' \/><div class='big-prev-fake'><img decoding=\"async\" class=\"wp-image-4789 avia-img-lazy-loading-not-4789\"  width=\"720\" height=\"438\" src=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Repro-3-1.jpg\" title='\u51fa\u751f\u7f3a\u9677\u68c0\u6d4b' alt='' srcset=\"https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Repro-3-1.jpg 720w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Repro-3-1-300x183.jpg 300w, https:\/\/clbiomed.com\/wp-content\/uploads\/2020\/07\/Repro-3-1-705x429.jpg 705w\" sizes=\"(max-width: 720px) 100vw, 720px\" \/><\/div><\/a><\/div><\/div><\/p><\/div>\n<div class='flex_column av-789xw-e4c3fbded90e97fc2005decad1d070f5 av_two_third  avia-builder-el-3  el_after_av_one_third  el_before_av_one_third  flex_column_div '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-kcqq29ub-d38b6f07d3f96565ba0c70006a83d2a7\">\n#top .togglecontainer.av-kcqq29ub-d38b6f07d3f96565ba0c70006a83d2a7 p.toggler.activeTitle{\ncolor:#ffffff;\nborder-color:#ffffff;\nbackground-color:#ce6da1;\n}\n#top .togglecontainer.av-kcqq29ub-d38b6f07d3f96565ba0c70006a83d2a7 p.toggler:not(.activeTitle):hover{\ncolor:#ffffff;\nbackground-color:#ce6da1;\n}\n#top .togglecontainer.av-kcqq29ub-d38b6f07d3f96565ba0c70006a83d2a7 p.toggler:not(.activeTitle):hover .toggle_icon, #top .togglecontainer.av-kcqq29ub-d38b6f07d3f96565ba0c70006a83d2a7 p.toggler:not(.activeTitle):hover .toggle_icon *{\nborder-color:#ffffff !important;\n}\n<\/style>\n<div  class='togglecontainer av-kcqq29ub-d38b6f07d3f96565ba0c70006a83d2a7 av-minimal-toggle  avia-builder-el-4  avia-builder-el-no-sibling  toggle_close_all hasCurrentStyle' >\n<section class='av_toggle_section av-8s59wq-5be1c81a84f0a42ced297e8d991c82e0'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p data-fake-id='#toggle-id-1' class='toggler  activeTitle '  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-1'>\u80cc\u666f\u4ecb\u7ecd<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-1' class='toggle_wrap  active_tc' style='display:block;' ><div class='toggle_content invers-color '  itemprop=\"text\" ><p>\u4eba\u4f53<strong>\u5916\u663e\u5b50\u7ec4<\/strong>\uff08Exome\uff09\u7ea6\u5360\u5168\u57fa\u56e0\u7ec4\u76841%\uff0c\u5374\u5305\u542b\u7ea685%\u5bfc\u81f4\u5df2\u77e5\u75be\u75c5\u7684\u7a81\u53d8\u3002<strong>\u5168\u5916\u663e\u5b50\u7ec4\u6d4b\u5e8f<\/strong> (Whole Exome Sequencing, WES)\u662f\u5229\u7528\u63a2\u9488\u6742\u4ea4\u5bcc\u96c6\u5916\u663e\u5b50\u533a\u57df\u7684DNA\u5e8f\u5217\uff0c\u901a\u8fc7\u9ad8\u901a\u91cf\u6d4b\u5e8f\uff0c\u53d1\u73b0\u4e0e\u86cb\u767d\u8d28\u529f\u80fd\u53d8\u5f02\u76f8\u5173\u9057\u4f20\u7a81\u53d8\u7684\u6280\u672f\u624b\u6bb5\u3002WES \u53ef\u4ee5\u68c0\u6d4b\u4eba\u4f53\u57fa\u56e0\u7ec4\u4e2d\u603b\u5171\u542b\u6709\u768420,000\u591a\u4e2a\u57fa\u56e0\uff0c\u5bf9\u9884\u6d4b\u4eba\u4f53\u7684\u60a3\u75c5\u98ce\u9669\uff0c\u5bf9\u5df2\u60a3\u75be\u75c5\u7684\u8f85\u52a9\u8bca\u65ad\u3001\u75c5\u56e0\u8bca\u65ad\uff0c\u5bf9\u9884\u540e\u5224\u65ad\u4ee5\u53ca\u4e86\u89e3\u4f53\u8d28\u60c5\u51b5\uff0c\u5747\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-oyld6-fb0255a7ee7f2f1b38f7bbe99f990278'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p data-fake-id='#toggle-id-2' class='toggler   '  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-2'>\u9002\u7528\u8303\u56f4<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-2' class='toggle_wrap  '  ><div class='toggle_content invers-color '  itemprop=\"text\" ><p><strong>\u7ed3\u6784\u5f02\u5e38\uff1a<\/strong><\/p>\n<ul>\n<li>\u5934\u9762\u90e8\u53d1\u80b2\u5f02\u5e38\u3001\u4e94\u5b98\u53d1\u80b2\u7578\u5f62\u3001\u7279\u6b8a\u9762\u5bb9\u3002<\/li>\n<li>\u8eaf\u5e72\u3001\u56db\u80a2\u548c\u751f\u6b96\u5668\u7b49\u7684\u5148\u5929\u5f02\u5e38\u3001\u77ee\u5c0f\u3001\u751f\u957f\u53d1\u80b2\u7f3a\u9677\u7b49\u3002<\/li>\n<li>\u5185\u810f\u5f02\u4f4d\u548c\u591a\u53d1\u5185\u810f\u5148\u5929\u7578\u5f62\u7b49\u3002<\/li>\n<li>\u76ae\u80a4\u5f02\u5e38\uff0c\u5982\u5927\u75b1\u8868\u76ae\u677e\u89e3\u75c7\u3001\u76ae\u80a4\u677e\u5f1b\u7b49\u3002<\/li>\n<\/ul>\n<p><strong>\u529f\u80fd\u5f02\u5e38\uff1a<\/strong><\/p>\n<ul>\n<li>\u795e\u7ecf\u808c\u8089\u76f8\u5173\u75be\u75c5\uff0c\u5982\u667a\u529b\u53d1\u80b2\u548c\uff08\u6216\uff09\u8ba4\u77e5\u969c\u788d\u3001\u8bed\u8a00\u969c\u788d\u3001\u766b\u75eb\u3001\u793e\u4f1a\u9002\u5e94\u6216\u884c\u4e3a\u969c\u788d\uff0c\u795e\u7ecf\u9000\u884c\u6027\u75c5\u53d8\u4ee5\u53ca\u808c\u75c5\u7b49\u3002<\/li>\n<li>\u89c6\u542c\u969c\u788d\uff0c\u5982\u5931\u660e\u548c\u5176\u4ed6\u89c6\u529b\u95ee\u9898\u4ee5\u53ca\u8033\u804b\u7b49\u3002<\/li>\n<li>\u5404\u79cd\u5148\u5929\u4ee3\u8c22\u969c\u788d\uff0c\u5982\u987d\u56fa\u6027\u4f4e\u8840\u7cd6\u3001\u9ad8\u6c28\u8840\u75c7\u7b49\uff0c\u8fd8\u6709\u4e0d\u660e\u539f\u56e0\u7684\u65b0\u751f\u513f\u53cd\u5e94\u5dee\u3001\u808c\u5f20\u529b\u4f4e\u4e0b\u3001\u5582\u517b\u56f0\u96be\u7b49\u3002<\/li>\n<li>\u514d\u75ab\u7cfb\u7edf\u529f\u80fd\u660e\u663e\u5f02\u5e38\uff0c\u5982\u4e0d\u80fd\u63a7\u5236\u7684\u4e25\u91cd\u611f\u67d3\u7b49\u3002<\/li>\n<\/ul>\n<p><strong>\u5176\u5b83\u5f02\u5e38\uff1a<\/strong><\/p>\n<ul>\n<li>\u65b0\u751f\u513f\u8d28\u8c31\u3001\u542c\u529b\u7b5b\u67e5\u63d0\u793a\u660e\u663e\u5f02\u5e38\u3002<\/li>\n<li>\u4e34\u5e8a\u8f85\u52a9\u68c0\u67e5\uff08\u8d28\u8c31\u3001\u751f\u5316\u3001\u514d\u75ab\u6307\u6807\u3001\u5f71\u50cf\u3001\u7535\u751f\u7406\u3001\u75c5\u7406\u7b49\uff09\u51fa\u73b0\u5f02\u5e38\uff0c\u63d0\u793a\u5148\u5929\u9057\u4f20\u75be\u75c5\u53ef\u80fd\u3002<\/li>\n<li>\u75be\u75c5\u5448\u5bb6\u65cf\u805a\u96c6\u73b0\u8c61\u3002<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-6e4s56-7aeb269d733d45b97f400256b7260b27'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p data-fake-id='#toggle-id-3' class='toggler   '  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-3'>\u6280\u672f\u6307\u6807<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-3' class='toggle_wrap  '  ><div class='toggle_content invers-color '  itemprop=\"text\" ><table>\n<tbody>\n<tr>\n<td width=\"142\"><strong>\u6280\u672f\u65b9\u6848<\/strong><\/td>\n<td width=\"142\"><strong>\u68c0\u6d4b\u5185\u5bb9<\/strong><\/td>\n<td width=\"142\"><strong>\u62a5\u544a\u65f6\u95f4<\/strong><\/td>\n<td width=\"142\"><strong>\u5907\u6ce8<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"142\">WES<\/td>\n<td width=\"142\">20000\u4e2a\u57fa\u56e0\uff0c\u9ad8\u6df1\u5ea6\u6d4b\u5e8f<\/td>\n<td width=\"142\">\u81ea\u6536\u5230\u6837\u672c\u540e20-25\u5929\u51fa\u62a5\u544a<\/td>\n<td width=\"142\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td width=\"142\">WES-link<\/td>\n<td width=\"142\">20000\u4e2a\u57fa\u56e0\uff0c\u9ad8\u6df1\u5ea6\u6d4b\u5e8f<\/p>\n<p>\u540c\u65f6\u53ef\u4ee5\u68c0\u51fa100Kb\u4ee5\u4e0a\u7684\u7f3a\u5931\u3001\u91cd\u590d\u3001\u6613\u4f4d\u3001\u5012\u4f4d\u3002<\/td>\n<td width=\"142\">\u81ea\u6536\u5230\u6837\u672c\u540e20-25\u5929\u51fa\u62a5\u544a<\/td>\n<td width=\"142\">\u5373\u53ef\u4ee5\u68c0\u6d4b\u51fa\u57fa\u56e0\u7a81\u53d8\uff0c\u53c8\u53ef\u4ee5\u68c0\u6d4b\u51fa\u67d3\u8272\u4f53\u7ed3\u6784\u5f02\u5e38\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-4g3zoq-64a5d74837f99150e1ca851270085512'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div role=\"tablist\" class=\"single_toggle\" data-tags=\"{All} \"  ><p data-fake-id='#toggle-id-4' class='toggler   '  itemprop=\"headline\"  role='tab' tabindex='0' aria-controls='toggle-id-4'>\u53d6\u6837\u8981\u6c42<span class=\"toggle_icon\"><span class=\"vert_icon\"><\/span><span class=\"hor_icon\"><\/span><\/span><\/p><div id='toggle-id-4' class='toggle_wrap  '  ><div class='toggle_content invers-color '  itemprop=\"text\" ><table width=\"568\">\n<tbody>\n<tr>\n<td width=\"142\"><strong>\u53d6\u6837\u65b9\u6cd5<\/strong><\/td>\n<td width=\"101\"><strong>\u53d6\u6837\u91cf<\/strong><\/td>\n<td width=\"183\"><strong>\u53d6\u6837\u5668\u6750<\/strong><\/td>\n<td width=\"142\"><strong>\u8fd0\u8f93\u65b9\u5f0f<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"142\">\u5916\u5468\u8840<\/td>\n<td width=\"101\">5ml<\/td>\n<td width=\"183\">\u666e\u901a\u7d2b\u5e3dEDTA\u91c7\u8840\u7ba1<\/td>\n<td width=\"142\">\u51b0\u888b\u8fd0\u8f93<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/div><\/div><\/section>\n<section class='av_toggle_section av-2j7pka-d17d9c44817ac54ab17df141ec37659e'  itemscope=\"itemscope\" 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