{"id":15077,"date":"2023-09-12T10:18:15","date_gmt":"2023-09-12T02:18:15","guid":{"rendered":"https:\/\/clbiomed.com\/?p=15077"},"modified":"2023-09-13T10:27:52","modified_gmt":"2023-09-13T02:27:52","slug":"%e5%b9%bf%e7%ba%b3%e8%8b%b1%e6%89%8d-%e6%ac%a2%e8%bf%8e%e6%82%a8%e5%8a%a0%e5%85%a5%e4%b9%90%e5%9c%9f%e5%8d%9a%e5%a3%ab%e5%90%8e%e5%88%9b%e6%96%b0%e5%ae%9e%e8%b7%b5%e5%9f%ba%e5%9c%b0","status":"publish","type":"post","link":"https:\/\/clbiomed.com\/2023\/09\/%e5%b9%bf%e7%ba%b3%e8%8b%b1%e6%89%8d-%e6%ac%a2%e8%bf%8e%e6%82%a8%e5%8a%a0%e5%85%a5%e4%b9%90%e5%9c%9f%e5%8d%9a%e5%a3%ab%e5%90%8e%e5%88%9b%e6%96%b0%e5%ae%9e%e8%b7%b5%e5%9f%ba%e5%9c%b0\/","title":{"rendered":"\u5e7f\u7eb3\u82f1\u624d| \u6b22\u8fce\u60a8\u52a0\u5165\u4e50\u571f\u535a\u58eb\u540e\u521b\u65b0\u5b9e\u8df5\u57fa\u5730"},"content":{"rendered":"

\u5982\u679c\u4f60\u60f3\u8981\u6311\u6218\u751f\u7269\u5236\u836f\u884c\u4e1a\u524d\u6cbf\u8bfe\u9898<\/p>\n

\u5982\u679c\u4f60\u81f4\u529b\u4e8e\u4ea7\u51fa\u7a81\u7834\u6027\u6210\u679c<\/p>\n

\u5982\u679c\u4f60\u60f3\u5728\u89e3\u51b3\u884c\u4e1a\u53d1\u5c55\u548c\u74f6\u9888\u95ee\u9898\u4e2d<\/p>\n

\u505a\u51fa\u72ec\u6709\u8d21\u732e<\/p>\n

\u6b22\u8fce\u52a0\u5165\u4e50\u571f\u535a\u58eb\u540e\u521b\u65b0\u5b9e\u8df5\u57fa\u5730<\/p>\n

\u4e0e\u4e50\u571f\u53ca\u4e1a\u754c\u8fdb\u884c\u601d\u60f3\u78b0\u649e<\/p>\n

\u5171\u540c\u53c2\u4e0e\u6311\u6218\u6027\u8bfe\u9898\u63a2\u7d22<\/p>\n

\u5171\u540c\u6253\u9020\u4e16\u754c\u7ea7\u751f\u7269\u533b\u836f\u9f99\u5934\u4f01\u4e1a\uff01<\/p>\n

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\u4e50\u571f\u751f\u547d\u79d1\u6280<\/p><\/div>\n<\/section>\n

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\u516c\u53f8\u7b80\u4ecb<\/strong><\/h4>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u4e50\u571f\u79d1\u6280\u521b\u59cb\u56e2\u961f\u4e8e2016\u5e74\u521d\u56de\u5f52\u7956\u56fd\uff0c\u5728\u5317\u4eac<\/strong>\u548c\u6df1\u5733<\/strong>\u521b\u7acb\u4e50\u571f\u7cbe\u51c6\u533b\u7597\u79d1\u6280\u30022021\u5e74\u5165\u9009\u201c\u65b0\u534e\u793e\u6c11\u65cf\u54c1\u724c\u5de5\u7a0b<\/strong>\u201d\uff0c2022\u5e74\u843d\u5730\u4e0a\u6d77<\/strong>\u5e76\u5411\u6d77\u5916\u62d3\u5c55\uff0c\u81f4\u529b\u4e8e\u6210\u4e3a\u4e16\u754c\u7ea7\u751f\u7269\u533b\u836f\u9f99\u5934\u4f01\u4e1a<\/strong>\u3002\u7531\u8bfa\u8d1d\u5c14\u5956\u5f97\u4e3b\u3001\u201cDNA\u4e4b\u7236\u201d\u8a79\u59c6\u65af\u00b7\u6c83\u68ee<\/strong>\u535a\u58eb\u4efb\u79d1\u5b66\u603b\u987e\u95ee\uff0c\u6295\u8d44\u5f15\u8fdb\u548c\u81ea\u4e3b\u7814\u53d1\u5e76\u4e3e\uff0c\u6253\u9020\u4e00\u4e2a\u96c6\u7cbe\u51c6\u68c0\u6d4b\uff08\u57fa\u56e0\u68c0\u6d4b\u5206\u5b50\u8bca\u65ad\uff09\u3001\u7cbe\u51c6\u533b\u836f\uff08\u751f\u7269\u836f\u7814\u53d1\u667a\u9020\uff09\u3001\u7cbe\u51c6\u533b\u7597\uff08\u533b\u7597\u53ca\u533b\u517b\u670d\u52a1\uff09<\/strong>\u4e8e\u4e00\u4f53\u7684\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u751f\u6001\uff0c\u4e0d\u65ad\u8ffd\u6c42\u201c\u5065\u5eb7\u4e50\u571f\uff0c\u5065\u5eb7\u4e2d\u56fd\u201d\u7684\u4f7f\u547d\u3002\u4e50\u571f\u5728\u56fd\u9645\u4e00\u6d41\u56e2\u961f\u5e26\u9886\u4e0b\uff0c\u5728\u4e2d\u56fd\u7387\u5148\u4f7f\u7528\u8d85\u5927\u89c4\u6a21\u751f\u7269\u53cd\u5e94\u5668\uff0c\u901a\u8fc7\u6280\u672f\u521b\u65b0\u548c\u89c4\u6a21\u5316\u5546\u4e1a\u751f\u4ea7\uff0c\u6781\u5927\u964d\u4f4e\u751f\u7269\u836f\u7684\u6210\u672c\uff0c\u505a\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u597d\u836f\u3002\u76ee\u524d\u4e50\u571f\u6b63\u5728\u6df1\u5733\u3001\u4e0a\u6d77\u548c\u6d77\u5916\u5efa\u8bbe\u9886\u5148\u7684\u751f\u7269\u836f\u5f00\u53d1\u667a\u9020\u57fa\u5730\uff0c\u76ee\u6807\u662f\u52302025\u5e74\u62e5\u6709\u8d85\u8fc7\u767e\u4e07\u5347\u4ea7\u80fd\uff0c\u6210\u4e3a\u4e16\u754c\u6700\u5927\u7684\u751f\u7269\u836f\u5f00\u53d1\u548c\u751f\u4ea7\u5546\u3002\u4e50\u571f\u5728\u4e2d\u56fd\u6df1\u5733\u3001\u5317\u4eac\u3001\u4e0a\u6d77\u3001\u6210\u90fd\u7b49\u57ce\u5e02\u8bbe\u6709\u5b50\u516c\u53f8\u6216\u533b\u5b66\u68c0\u9a8c\u6240\uff0c\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u8bbe\u6709\u6295\u8d44\u548c\u5546\u52a1\u62d3\u5c55\u90e8\u95e8\u3002<\/p>\n

\u4e50\u571f\u6c83\u68ee\u751f\u547d\u79d1\u6280\u4e2d\u5fc3<\/strong>\u4f4d\u4e8e\u6df1\u5733\u575d\u5149\u56fd\u9645\u751f\u7269\u8c37\uff0c2018-2023\u8fde\u7eed\u516d\u5e74\u83b7\u5f97\u201c\u6df1\u5733\u5e02\u65b0\u5174\u4ea7\u4e1a\u91cd\u5927\u9879\u76ee<\/strong>\u201d\u79f0\u53f7\u3002\u603b\u89c4\u5212\u9762\u79ef1100\u4f59\u4ea9\uff0c\u76ee\u6807\u6253\u9020\u4e00\u4e2a\u56fd\u9645\u4e00\u6d41\u7684\u751f\u7269\u836f\u7814\u53d1\u751f\u4ea7\u3001\u9879\u76ee\u5b75\u5316\u4ee5\u53ca\u533b\u7597\u670d\u52a1\u57fa\u5730\u3002I\u671f\u5de5\u7a0b\u5df2\u9646\u7eed\u5b8c\u5de5\uff0c\u4e8e2020\u5e745\u6708\u6b63\u5f0f\u6295\u5165\u4f7f\u7528\u3002<\/p>\n

\u62db\u8058\u5c97\u4f4d<\/strong><\/h4>\n
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01<\/span>.<\/strong>\u6838\u9178\u9012\u9001\u79d1\u5b66\u5bb6<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\u2460\u8d1f\u8d23\u6838\u9178\u7c7b\u836f\u7269\u7684\u9012\u9001\u6280\u672f\uff0c\u521b\u65b0\u5236\u5242\u7814\u53d1\uff1b<\/p>\n

\u2461\u8d1f\u8d23\u6838\u9178\u836f\u7269\u9012\u9001\u6280\u672f\u7684\u7acb\u9879\u8c03\u7814\uff0c\u63a8\u8fdb\u9879\u76ee\u8fdb\u5c55\uff0c\u89e3\u51b3\u7814\u53d1\u8fc7\u7a0b\u4e2d\u9047\u5230\u7684\u6280\u672f\u95ee\u9898\uff1b<\/p>\n

\u2462\u5f00\u5c55\u8d1f\u8f7d\u6838\u9178\u836f\u7269\u7684\u7eb3\u7c73\u5236\u5242\u7814\u53d1\uff0c\u5305\u62ec\u9012\u9001\u8f7d\u4f53\u5316\u5408\u7269\uff08\u5982\u8102\u8d28\u7c7b\u5316\u5408\u7269\uff09\u7684\u8bbe\u8ba1\u548c\u5408\u6210\uff0c\u53c2\u4e0e\u8102\u8d28\u4f53\u6216\u5176\u4ed6\u7eb3\u7c73\u8f7d\u4f53\u7684\u5236\u5907\uff0c\u8d1f\u8f7d\u6838\u9178\u7684\u7eb3\u7c73\u5236\u5242\u8bc4\u4ef7\u7b49\uff1b<\/p>\n

\u2463\u8bc4\u4f30\u6838\u9178\u7eb3\u7c73\u5236\u5242\u7684\u7406\u5316\u6027\u8d28\u548c\u836f\u7269\u9012\u9001\u80fd\u529b\uff0c\u836f\u7406\u548c\u6bd2\u7406\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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02<\/span>.<\/strong>mRNA\u79d1\u5b66\u5bb6<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
\n
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\u2460\u53c2\u4e0emRNA\u4ea7\u54c1\u7684\u7814\u7a76\u4e0e\u5f00\u53d1\uff0c\u5efa\u7acb\u53ef\u653e\u5927\u3001\u53ef\u8f6c\u79fb\u7684\u5de5\u827a\u6d41\u7a0b\uff0c\u4ee5\u751f\u4ea7\u9ad8\u8d28\u91cf\u7684mRNA\uff1b<\/p>\n

\u2461\u5229\u7528DoE\u65b9\u6cd5\u5bf9\u8d28\u7c92\u6269\u589e\u3001\u8d28\u7c92\u7ebf\u6027\u5316\u548c\u4f53\u5916\u8f6c\u5f55mRNA\u8fc7\u7a0b\u8fdb\u884c\u5de5\u827a\u6d41\u7a0b\u4f18\u5316\uff1b<\/p>\n

\u2462\u6478\u7d22\u5efa\u7acbHPLC\u7b49\u65b9\u6cd5\uff0c\u8fdb\u884cmRNA\u7eaf\u5316\u4ee5\u53ca\u5de5\u827a\u6d41\u7a0b\u653e\u5927\uff0c\u4ee5\u751f\u4ea7\u9ad8\u7eaf\u5ea6\u7684mRNA\uff1b<\/p>\n

\u2463\u53c2\u4e0e\u5efa\u7acbmRNA\u7684\u68c0\u6d4b\u548c\u5206\u6790\u65b9\u6cd5,\u5305\u62ec\u7406\u5316\u3001\u8272\u8c31\u3001\u5206\u5b50\u548c\u7ec6\u80de\u7b49\uff1b<\/p>\n

\u2464\u4e0e\u5206\u5b50\u751f\u7269\u5b66\u56e2\u961f\u5408\u4f5c\u8bbe\u8ba1\u65b0\u4e00\u4ee3mRNA\uff0c\u5bf9\u5e3d\/\u5c3e\u6784\u578b\u3001UTRs\u3001\u5bc6\u7801\u5b50\u7b49\u8fdb\u884c\u4f18\u5316\uff0c\u4ee5\u6539\u5584\u836f\u7269\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff1b<\/p>\n

\u2465\u5b9e\u65f6\u5173\u6ce8\u65b0\u6280\u672f\u4ee5\u53ca\u53d1\u8868\u7684\u76f8\u5173\u6587\u7ae0\uff0c\u5c06\u65b0\u7684\u529f\u80fd\u548c\u7279\u6027\u8fd0\u7528\u5230mRNA\u5e73\u53f0\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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03<\/span>.<\/strong>\u6838\u9178\u836f\u7269\u9996\u5e2d\u533b\u5b66\u5b98CMO<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
\n
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\u2460\u6839\u636e\u516c\u53f8\u836f\u7269\u7814\u53d1\u6218\u7565\u53c2\u4e0e\u4e34\u5e8a\u7814\u53d1\u65b9\u9762\u7684\u6574\u4f53\u53d1\u5c55\u6218\u7565\u7684\u89c4\u5212\u5236\u5b9a\uff0c\u8d1f\u8d23\u5236\u5b9a\u6838\u9178\uff08RNA\uff09\u836f\u3001\u6838\u9178\u9012\u9001\u3001\u57fa\u56e0\u836f\u3001\u7ec6\u80de\u836f\u7b49\u751f\u7269\u5236\u836f\u6574\u4f53\u4e34\u5e8a\u533b\u5b66\u5f00\u53d1\u6218\u7565\uff1b<\/p>\n

\u2461\u8d1f\u8d23\u5236\u5b9a\u516c\u53f8\u4e34\u5e8a\u533b\u5b66\u53d1\u5c55\u89c4\u5212\u3001\u4e34\u5e8a\u9879\u76ee\u8fd0\u8425\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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04<\/span>.<\/strong>\u6838\u9178\u836f\u7269\u8bbe\u8ba1\u79d1\u5b66\u5bb6<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\u2460\u4e3asiRNA\u836f\u7269\u7814\u53d1\u9879\u76ee\u63d0\u4f9b\u751f\u7269\u4fe1\u606f\u5b66\u652f\u6491\uff1b<\/p>\n

\u2461\u4e0e\u56e2\u961f\u5176\u5b83\u4e13\u5bb6\u5408\u4f5c\u8fdb\u884c\u5be1\u6838\u82f7\u9178\u6216\u5176\u5b83RNA\u836f\u7269\u9776\u70b9\u7684\u8c03\u7814\uff0c\u8fdb\u884cRNA\u836f\u7269\u7684\u5e8f\u5217\u8bbe\u8ba1\uff0c\u5e76\u4e3a\u5efa\u7acb\u4e00\u6574\u5957\u7684\u4f53\u5185\u5916\u8bc4\u4ef7\u65b9\u6cd5\u63d0\u4f9b\u751f\u7269\u4fe1\u606f\u5b66\u652f\u6491\uff1b<\/p>\n

\u2462\u534f\u52a9\u56e2\u961f\u5efa\u7acb\u5e76\u7ef4\u62a4\u6570\u636e\u5e93\uff1b<\/p>\n

\u2463\u5efa\u7acb\u5e76\u7ef4\u6301\u4e0eRNA\u836f\u7269\u7814\u53d1\u76f8\u5173\u7684\u8ba1\u7b97\u6a21\u578b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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05<\/span>.<\/strong>mRNA\u6784\u5efa\u79d1\u5b66\u5bb6<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\u2460\u86cb\u767d\u8d28\u5e8f\u5217\u8c03\u53d6\uff0c\u57fa\u56e0\u5e8f\u5217\u8c03\u53d6\uff0c\u4f18\u5316\uff0c\u6539\u9020\uff0c\u8f7d\u4f53\u6784\u5efa\uff0cmRNA\u5206\u5b50\u8bbe\u8ba1\u4e0e\u4f18\u5316\uff1b<\/p>\n

\u2461\u9776\u70b9\u9a8c\u8bc1\uff0c\u8bbe\u8ba1\u6210\u836f\u6027\u9a8c\u8bc1\u5b9e\u9a8c\uff1b<\/p>\n

\u2462\u4e3b\u5bfc\u548c\u914d\u5408\u751f\u7269\u4fe1\u606f\u5b66\u68c0\u7d22\u76f8\u5173\u5de5\u4f5c\uff1b<\/p>\n

\u2463\u5bf9\u63a5\u516c\u53f8\u5185\u5916\u7814\u53d1\u56e2\u961f\uff0c\u5bf9\u5916\u5305\u5546\u7ba1\u7406\uff1b<\/p>\n

\u2464\u8d1f\u8d23mRNA\u7684\u4f53\u5916\u8f6c\u5f55\u5408\u6210\uff0c\u7eaf\u5316\uff0c\u652f\u6301\u836f\u7406\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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06<\/span>.<\/strong>\u6838\u9178\u836f\u7269\u9012\u9001\u79d1\u5b66\u5bb6<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\u2460\u5f00\u5c55\u5c0f\u6838\u9178\u9012\u9001\u7cfb\u7edf\u7814\u53d1\u5de5\u4f5c\uff0c\u4e0e\u56e2\u961f\u5b8c\u6210\u8bbe\u8ba1\u3001\u5b9e\u65bd\u3001\u9a8c\u8bc1\u4e0e\u4f18\u5316\u76f8\u5173\u5b9e\u9a8c\u4efb\u52a1\uff1b<\/p>\n

\u2461\u8d1f\u8d23\u9012\u9001\u7cfb\u7edf\u548c\u5236\u5242\u6280\u672f\u653b\u5173\uff0c\u89e3\u51b3\u6280\u672f\u96be\u9898\uff0c\u5bf9\u5b9e\u9a8c\u4e2d\u51fa\u73b0\u7684\u95ee\u9898\u8fdb\u884c\u5206\u6790\u5e76\u53ca\u65f6\u89e3\u51b3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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07<\/span>.<\/strong>\u6838\u9178\u5236\u5242\u79d1\u5b66\u5bb6<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
\n
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\u2460\u8d1f\u8d23LNP\/\u8102\u8d28\u4f53\u7684\u7814\u53d1\u53ca\u4f18\u5316\u53ca\u5176\u4ed6\u9012\u9001\u7cfb\u7edf\u7684\u7814\u53d1\uff1b<\/p>\n

\u2461\u8d1f\u8d23LNP\u53ca\u5176\u4ed6\u9012\u9001\u6280\u672f\u5de5\u827a\u7684\u5f00\u53d1\uff1b<\/p>\n

\u2462\u53c2\u4e0emRNA\u5236\u5242\u7684\u5c0f\u8bd5\u5236\u5907\u53ca\u4e2d\u8bd5\u751f\u4ea7\uff1b<\/p>\n

\u2463\u8d1f\u8d23\u4e2d\u8bd5\u8bbe\u5907\u7684\u65e5\u5e38\u7ef4\u62a4\u53ca\u7269\u6599\u91c7\u8d2d\/\u7ba1\u7406\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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08<\/span>.<\/strong>\u6709\u673a\u5408\u6210\u79d1\u5b66\u5bb6<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
\n
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\u2460\u8d1f\u8d23\u6709\u673a\u5206\u5b50\u5de5\u827a\u8def\u7ebf\u3001\u5408\u6210\u3001\u7eaf\u5316\u3001\u6742\u8d28\u7814\u7a76\u3001\u56fe\u8c31\u89e3\u6790\u7b49\u5de5\u4f5c\u53ca\u5236\u5b9a\u5b9e\u9a8c\u5408\u6210\u65b9\u6848\uff1b<\/p>\n

\u2461\u5206\u6790\u548c\u89e3\u51b3\u5408\u6210\u8fc7\u7a0b\u4e2d\u9047\u5230\u7684\u95ee\u9898\uff0c\u5e76\u5b9a\u671f\u5bf9\u6240\u8d1f\u8d23\u5de5\u4f5c\u8fdb\u884c\u603b\u7ed3\u548c\u6c47\u62a5\uff1b<\/p>\n

\u2462\u914d\u5408\u5b8c\u6210\u7814\u53d1\u9879\u76ee\u5c0f\u8bd5\u3001\u4e2d\u8bd5\u53ca\u653e\u5927\u5404\u9879\u5de5\u4f5c\uff1b<\/p>\n

\u2463\u6e05\u6670\u5b8c\u6574\u8bb0\u5f55\u5b9e\u9a8c\u73b0\u8c61\u53ca\u5b9e\u9a8c\u7ed3\u679c\uff0c\u64b0\u5199\u5b9e\u9a8c\u62a5\u544a\u4e66\uff0c\u505a\u5230\u53ca\u65f6\u3001\u771f\u5b9e\u548c\u8be6\u7ec6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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09<\/span>.<\/strong>\u5206\u5b50\u751f\u7269\u5b66\u79d1\u5b66\u5bb6<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
\n
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\u2460\u901a\u8fc7\u57fa\u56e0\u91cd\u7ec4\uff0c\u57fa\u56e0\u8868\u8fbe\u4f18\u5316\uff0c\u53ca\u86cb\u767d\u5728\u54fa\u4e73\u7c7b\u7ec6\u80de\u7684\u8868\u8fbe\uff0c\u8bbe\u8ba1\u6297\u4f53\u8868\u8fbe\u7b56\u7565\uff1b<\/p>\n

\u2461\u8bbe\u8ba1\u91cd\u7ec4\u6297\u4f53\u8868\u8fbe\uff0c\u7eaf\u5316\u53ca\u751f\u7269\u5316\u5b66\u9274\u5b9a\uff0c\u4e3a\u529f\u80fd\u7814\u7a76\u63d0\u4f9b\u5fc5\u8981\u7684\u8bd5\u5242\uff1b<\/p>\n

\u2462\u72ec\u7acb\u8bbe\u8ba1\u548c\u5b9e\u65bd\u751f\u7269\u7c7b\u4f3c\u836f\u751f\u7269\u5316\u5b66\u9274\u5b9a\u8bd5\u9a8c\uff1b<\/p>\n

\u2463\u9ad8\u5206\u8fa8\u7387\u7ec6\u80de\u86cb\u767d\u7ed3\u5408\u6280\u672f\u7528\u4e8e\u8868\u5f81\u76ee\u6807\u86cb\u767d\u4e0e\u6297\u4f53\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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10<\/span>.<\/strong>\u514d\u75ab\u5b66\u9ad8\u7ea7\u79d1\u5b66\u5bb6<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
\n
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\u2460\u63a8\u52a8\u514d\u75ab\u5b66\u9879\u76ee\uff0c\u6839\u636e\u4ea7\u54c1\u4e0d\u540c\u7684\u514d\u75ab\u8c03\u7406\u529f\u80fd\uff0c\u8bbe\u8ba1\u548c\u5f00\u53d1\u514d\u75ab\u8c03\u8282\u529f\u80fd\u5b9e\u9a8c\uff0c\u6307\u5bfc\u4f53\u5916\u514d\u75ab\u7ec6\u80de\u5b9e\u9a8c\u4ee5\u7814\u7a76\u9776\u4f5c\u50cf\u8c03\u8282\u673a\u5236\uff1b<\/p>\n

\u2461\u8bbe\u8ba1\u5404\u7c7b\u514d\u75ab\u7ec6\u80de\u529f\u80fd\u5b9e\u9a8c\uff08\u7ec6\u80de\u4eea\uff09\uff0c\u89e3\u51b3\u5b9e\u9a8c\u4e2d\u51fa\u73b0\u7684\u95ee\u9898\uff0c\u719f\u7ec3\u638c\u63e1\u7ec6\u80de\u4eea\u64cd\u4f5c\u8f6f\u4ef6\u548c\u5206\u6790\u8f6f\u4ef6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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11<\/span>.<\/strong>\u7ec6\u80de\u5b66\u79d1\u5b66\u5bb6<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\u2460\u63a8\u8fdb\u4f53\u5916\u7ec6\u80de\u5b66\u529f\u80fd\u68c0\u6d4b\u9879\u76ee\uff0c\u9488\u5bf9\u4e0d\u540c\u4ea7\u54c1\u8bbe\u8ba1\u5f00\u53d1\u9002\u5408\u7684\u529f\u80fd\u5b9e\u9a8c\uff1b<\/p>\n

\u2461\u8bbe\u8ba1\u5404\u7c7b\u514d\u75ab\u7ec6\u80de\u529f\u80fd\u5b9e\u9a8c\uff0c\u89e3\u51b3\u5b9e\u9a8c\u4e2d\u7684\u95ee\u9898\uff1b<\/p>\n

\u2462\u719f\u6089\u7ec6\u80de\u57f9\u517b\u548c\u6d41\u5f0f\u7ec6\u80de\u4eea\u68c0\u6d4b\uff0c\u6570\u636e\u5206\u6790\uff1b<\/p>\n

\u2463\u5bf9\u7ec6\u80de\u751f\u7269\u5b66\u5b9e\u9a8c\u8fdb\u884c\u5b9e\u9a8c\u8bbe\u8ba1\u548c\u5b9e\u9a8c\u6570\u636e\u5206\u6790\uff1b<\/p>\n

\u2464\u6574\u7406\u548c\u62a5\u544a\u5b9e\u9a8c\u7ed3\u679c\u4ee5\u4f9b\u8ba8\u8bba\u5e76\u786e\u5b9a\u5206\u5b50\u7684\u529f\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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12<\/span>.<\/strong>\u52a8\u7269\u6a21\u578b\u548c\u52a8\u7269\u5b9e\u9a8c\u79d1\u5b66\u5bb6<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\u2460\u5f00\u53d1\u52a8\u7269\u6a21\u578b\u4ee5\u8bc4\u4f30\u65b0\u836f\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u4ee5\u652f\u6301 IND \u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7814\u7a76\uff1b<\/p>\n

\u2461\u4e0e\u5185\u90e8\u56e2\u961f\u4e00\u8d77\u53c2\u4e0e\u7814\u7a76\u548c\u65e9\u671f\u5f00\u53d1\uff0c\u9886\u5bfc\u4ece\u6982\u5ff5\u5230\u6267\u884c\u7684\u5b9e\u9a8c\u8bbe\u8ba1\uff1b\u5206\u6790\u6570\u636e\u3001\u4ea4\u6d41\u7ed3\u679c\u5e76\u5728\u56e2\u961f\u4f1a\u8bae\u4e2d\u5c55\u793a\u5de5\u4f5c\u7ed3\u679c\uff1b<\/p>\n

\u2462\u7ba1\u7406\u5916\u5305\u52a8\u7269\u7814\u7a76\uff0c\u9886\u5bfc\u4e0e\u5916\u90e8CRO \u7684\u5408\u4f5c\uff1b<\/p>\n

\u2463\u9886\u5bfc\u56e2\u961f\uff0c\u4ee5\u786e\u4fdd\u53d6\u5f97\u6210\u529f\u7684\u7814\u7a76\u6210\u679c\u7ec6\u5316\u7a0b\u5e8f\uff0c\u786e\u4fdd\u7edf\u4e00\u548c\u9ad8\u8d28\u91cf\u7684\u7ba1\u7406\u7a0b\u5e8f\uff0c\u5e76\u786e\u4fdd\u52a8\u7269\u5b9e\u9a8c\u6570\u636e\u7684\u51c6\u786e\u548c\u5ef6\u7eed\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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13<\/span>.<\/strong>CGT\u7814\u53d1\u603b\u76d1<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
\n
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\u2460\u5177\u6709\u514d\u75ab\u836f\u7269\u3001\u7ec6\u80de\u836f\u7269\u7b49\u5236\u836f\u7ecf\u9a8c\uff1b<\/p>\n

\u2461\u5177\u6709\u8f83\u5f3a\u7684car-t\u7b49\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u80fd\u529b\u53ca\u7ecf\u9a8c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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14<\/span>.<\/strong>Head of CMC<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
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\u2460\u8d1f\u8d23\u751f\u7269\u836f\u677f\u5757\u6240\u6709\u9879\u76ee\uff08\u91cd\u7ec4\u5927\u5206\u5b50\u86cb\u767d\u3001\u6297\u4f53\u7c7b\u836f\u7269\u7b49\uff09\u4e0a\u6e38\u7ec6\u80de\u57f9\u517b\u5de5\u827a\u5f00\u53d1\u53ca\u4e2d\u8bd5\u6837\u54c1\u3001\u4e34\u5e8a\u6837\u54c1\u7684\u751f\u4ea7\u3001\u5546\u4e1a\u5316\u751f\u4ea7\uff1b\u5e76\u8d1f\u8d23\u76f8\u5173\u8d28\u91cf\u65b9\u6cd5\u5f00\u53d1\u3001\u9a8c\u8bc1\u548c\u8f6c\u79fb\u7b49\u5de5\u4f5c\uff1b<\/p>\n

\u2461\u6839\u636e\u9879\u76ee\u8981\u6c42\uff0c\u5b8c\u6210\u76f8\u5173\u9879\u76ee\u7814\u7a76\u5f00\u53d1\u4ee5\u53ca\u8bbe\u8ba1\u8def\u7ebf\uff0c\u5e76\u6309\u9636\u6bb5\u6c47\u62a5\u9879\u76ee\u8fdb\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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15<\/span>.<\/strong>CMO<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n
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\u2460\u53c2\u4e0e\u5236\u5b9aCDMO\u5e74\u5ea6\u4e1a\u7ee9\u76ee\u6807\u548c\u5e02\u573a\u5f00\u53d1\u8ba1\u5212\uff0c\u7edf\u7b79\u5546\u52a1\u56e2\u961f\u79ef\u6781\u5f00\u62d3\u56fd\u5185\u5916\u5e02\u573a\u4e1a\u52a1\uff1b<\/p>\n

\u2461\u6839\u636e\u516c\u53f8\u6218\u7565\u4e1a\u7ee9\u76ee\u6807\uff0c\u5236\u5b9a\u516c\u53f8\u5546\u52a1\u56e2\u961f\u5de5\u4f5c\u8ba1\u5212\u5e76\u5b9e\u65bd\uff1b\u8d1f\u8d23CDMO\u4e1a\u52a1\u7684\u9879\u76ee\u8bc4\u4f30\u3001\u5408\u540c\u8c08\u5224\u3001\u534f\u8bae\u7b7e\u8ba2\uff0c\u552e\u4e2d\u9879\u76ee\u63a8\u8fdb\u4e0e\u8ddf\u8e2a\uff0c\u552e\u540e\u5ba2\u6237\u53cd\u9988\u4e0e\u6301\u7eed\u6539\u8fdb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u85aa\u916c\u798f\u5229<\/strong><\/h4>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\u85aa\u916c\u673a\u5236\uff1a\u63d0\u4f9b\u6709\u7ade\u4e89\u529b\u7684\u85aa\u916c\uff0c\u5458\u5de5\u6301\u80a1\u8ba1\u5212\u3002<\/section>\n
\u798f\u5229\u4fdd\u969c\u5305\u62ec\uff1a<\/section>\n
    \n
  • \u9ad8\u989d\u4e94\u9669\u4e00\u91d1\u3001\u9ad8\u6e29\u8865\u8d34<\/li>\n
  • \u9910\u8865\uff1a\u9910\u8865\u8865\u52a9\u3001\u5458\u5de5\u98df\u5802<\/li>\n
  • \u4ea4\u901a\uff1a\u591a\u7ebf\u8def\u901a\u52e4\u73ed\u8f66<\/li>\n
  • \u4f4f\u623f\uff1a\u516c\u53f8\u534f\u52a9\u7533\u8bf7\u4eba\u624d\u623f<\/li>\n
  • \u8282\u5047\u65e5\uff1a\u53cc\u4f11\u3001\u5e26\u85aa\u5e74\u5047\u3001\u8282\u65e5\u798f\u5229<\/li>\n
  • \u535a\u58eb\u540e\u5de5\u4f5c\u7ad9\uff1a\u5728\u7ad9\u8865\u8d3460\u4e07\uff08\u51712\u5e74\uff09\uff0c\u51fa\u7ad9\u8865\u8d3410\u4e07\uff08\u51713\u5e74\uff09<\/li>\n<\/ul>\n
    \n
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    \u7b80\u5386\u6295\u9012<\/strong><\/h4>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
    \u8054\u7cfb\u7535\u8bdd\uff1a0755-89770327<\/section>\n
    \u6295\u9012\u90ae\u7bb1\uff1ahrsz@cheerlandgroup.com<\/section>\n
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