{"id":6749,"date":"2021-02-07T11:05:02","date_gmt":"2021-02-07T03:05:02","guid":{"rendered":"https:\/\/clbiomed.com\/?p=6749"},"modified":"2021-02-07T11:08:53","modified_gmt":"2021-02-07T03:08:53","slug":"car-t%e7%96%97%e6%b3%95%e6%96%b0%e8%bf%9b%e5%b1%95-%e4%b9%90%e5%9c%9f%e6%b2%83%e6%a3%ae%e8%8b%b1%e9%9b%84%e4%bc%9a%e5%8d%81%e4%b9%9d%e6%9c%9f%e4%ba%ae%e7%82%b9","status":"publish","type":"post","link":"https:\/\/clbiomed.com\/2021\/02\/car-t%e7%96%97%e6%b3%95%e6%96%b0%e8%bf%9b%e5%b1%95-%e4%b9%90%e5%9c%9f%e6%b2%83%e6%a3%ae%e8%8b%b1%e9%9b%84%e4%bc%9a%e5%8d%81%e4%b9%9d%e6%9c%9f%e4%ba%ae%e7%82%b9\/","title":{"rendered":"CAR-T\u7597\u6cd5\u65b0\u8fdb\u5c55 | \u4e50\u571f\u6c83\u68ee\u82f1\u96c4\u4f1a\u5341\u4e5d\u671f\u4eae\u70b9"},"content":{"rendered":"
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\u4e50\u571f\u751f\u547d\u79d1\u6280\u8f6e\u503c\u8463\u4e8b\u957f\u82cf\u5f66\u666f\u535a\u58eb\u5bf9\u5404\u4f4d\u5609\u5bbe\u8385\u4e34\u4e50\u571f\u6c83\u68ee\u751f\u547d\u79d1\u6280\u4e2d\u5fc3\u53c2\u52a0\u672c\u6b21\u8bba\u575b\u8868\u793a\u70ed\u70c8\u6b22\u8fce\u3002\u4ed6\u8868\u793a\uff0c\u672c\u6b21\u8bba\u575b\u591a\u4f4d\u5927\u5496\u6765\u5206\u4eab\u5404\u81ea\u7684\u6210\u679c\uff0c\u6211\u975e\u5e38\u73cd\u60dc\u8fd9\u4e2a\u5b9d\u8d35\u7684\u5b66\u4e60\u673a\u4f1a\uff0c\u5e0c\u671b\u5927\u5bb6\u5728\u4e50\u571f\u8fd9\u4e2a\u5e73\u53f0\u4e0a\u6709\u66f4\u591a\u4ea4\u6d41\u3001\u66f4\u591a\u6536\u83b7\u3002\u00a0 \u00a0 \u00a0\u00a0<\/span><\/div>\n<\/div>\n
\u00a0 \u00a0 \u00a0\u00a0<\/span><\/div>\n
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\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0<\/span><\/div>\n
\u5728\u8bba\u575b\u7684\u4e3b\u9898\u6f14\u8bb2\u73af\u8282\uff0c\u6df1\u5733\u5927\u5b66\u603b\u533b\u9662\u56fd\u9645\u80bf\u7624\u4e2d\u5fc3\u526f\u9662\u957f\u4e8e\u529b\u535a\u58eb\u4ecb\u7ecd\u4e86CAR-T\u7ec6\u80de\u6cbb\u7597\u6700\u65b0\u8fdb\u5c55\u53ca\u5b9e\u65bd\u8981\u70b9\uff0c\u5357\u79d1\u5927\u7814\u7a76\u5458\u9648\u653e\u6021\u535a\u58eb\u6a21\u5f0f\u52a8\u7269\u542c\u89c9\u548c\u524d\u5ead\u529f\u80fd\u6d4b\u8bd5\u53ca\u5176\u5728\u836f\u7269\u7814\u53d1\u4e2d\u7684\u5e94\u7528\u3002\u66a8\u5357\u5927\u5b66\u751f\u7269\u5de5\u7a0b\u5b66\u7cfb\u4e3b\u4efb\u5510\u52c7\u535a\u58eb\u4ecb\u7ecd\u4e86\u9ad8\u7075\u654f\u514d\u75ab\u5b66\u68c0\u6d4b\u6280\u672f\u7814\u7a76\u6210\u679c\u3002<\/span><\/div>\n
\u00a0 \u00a0 \u00a0\u00a0<\/span><\/div>\n<\/div>\n
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\u6b64\u5916\uff0c\u53a6\u95e8\u535a\u745e\u6765\u533b\u7597\u521b\u59cb\u4eba\u67cf\u65ed\u535a\u58eb\u3001\u4e07\u6d77\u7ec6\u80de\u8463\u4e8b\u957f\u674e\u76f8\u9c81\u535a\u58eb \u3001\u5f00\u60a6\u751f\u547d\u79d1\u6280\u8463\u4e8b\u957f\u5f20\u4e25\u51ac\u535a\u58eb\u5206\u522b\u5c31\u9776\u5411\u6297\u7ea4\u7ef4\u5316\u65b0\u836f\u3001\u7ec6\u80de\u6cbb\u7597\u3001\u80bf\u7624\u65b0\u9776\u70b9\u7b49\u70ed\u70b9\u5206\u4eab\u4e86\u5404\u81ea\u5de5\u4f5c\u7684\u6700\u65b0\u8fdb\u5c55\u3002<\/span><\/div>\n
\u00a0 \u00a0 \u00a0\u00a0<\/span><\/div>\n
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\u00a0 \u00a0 \u00a0\u00a0<\/span><\/div>\n
\u4eae\u70b9\u5feb\u9012<\/strong><\/span><\/div>\n
\u00a0 \u00a0 \u00a0\u00a0<\/span><\/div>\n<\/div>\n
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\u8fd1\u5e74\u6765\uff0c\u6211\u56fd\u80bf\u7624\u65b0\u53d1\u75c5\u4f8b\u6570\u9010\u5e74\u4e0a\u5347\uff0c\u5176\u4e2d2018\u5e74\u65b0\u53d1308.4\u4e07\u4f8b\uff0c\u76f8\u8f83\u4e0a\u4e00\u5e74240\u4e07\u4f8b\u6709\u660e\u663e\u589e\u957f\u3002\u76ee\u524d\u624b\u672f\u548c\u653e\u5316\u7597\u65b9\u6cd5\u4ee5\u53ca\u9776\u5411\u7597\u6cd5\u3001\u4f20\u7edfT\u7ec6\u80de\u8fc7\u7ee7\u514d\u75ab\u7597\u6cd5\uff0c\u90fd\u6709\u5404\u81ea\u7684\u9650\u6027\uff0c\u56e0\u6b64\u63a2\u7d22\u65b0\u578b\u80bf\u7624\u6cbb\u7597\u65b9\u6cd5\u5177\u6709\u91cd\u8981\u793e\u4f1a\u610f\u4e49\u3002<\/span><\/div>\n
\u00a0 \u00a0 \u00a0\u00a0<\/span><\/div>\n<\/div>\n
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\u00a0 \u00a0 \u00a0\u00a0<\/span><\/div>\n
\u4e34\u5e8a\u4e0a\u53d1\u73b0\u80bf\u7624\u4e00\u822c\u5df2\u662f\u4e2d\u665a\u671f\uff0c\u6b64\u65f6\u75c5\u4eba\u4f53\u5185\u80bf\u7624\u7ec6\u80de\u5360\u4f18\u52bf\uff0c\u673a\u4f53\u7684\u514d\u75ab\u529f\u80fd\u6536\u5230\u4e25\u91cd\u524a\u5f31\uff0c\u4f53\u5185DC \u7ec6\u80de\u529f\u80fd\u53d7\u635f\uff0c\u6fc0\u6d3b T \u7ec6\u80de\u6548\u7387\u8f83\u4f4e\uff0c\u653b\u51fb\u764c\u7ec6\u80de\u80fd\u529b\u4e0d\u591f\uff0c\u4e5f\u4e0d\u591f\u7cbe\u51c6\uff1b\u53e6\u5916\uff0c\u80bf\u7624\u7ec6\u80de\u8fd8\u80fd\u901a\u8fc7\u9003\u9038\u673a\u5236\uff0c\u9003\u8131\u514d\u75ab\u7ec6\u80de\u7684\u653b\u51fb\uff0c\u56e0\u6b64\u5229\u7528\u57fa\u56e0\u6539\u9020\u6280\u672f\uff0c\u8868\u8fbe\u80bf\u7624\u7279\u5f02\u6027\u5d4c\u5408\u6297\u539f\u53d7\u4f53(chimeric antigen receptor\uff0cCAR)\u7684T\u7ec6\u80de\u6280\u672f\u5e94\u8fd0\u800c\u751f\u3002\u8fd9\u4e9b\u7ec6\u80de\u663e\u793a\u51fa\u9776\u5411\u6027\u3001\u6740\u4f24\u6d3b\u6027\u548c\u6301\u4e45\u6027\uff0c\u4e3a\u80bf\u7624\u7684\u514d\u75ab\u6cbb\u63d0\u4f9b\u4e86\u65b0\u7684\u89e3\u51b3\u65b9\u6848\u3002<\/span><\/div>\n
\u00a0 \u00a0 \u00a0\u00a0<\/span><\/div>\n<\/div>\n
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\n
CAR-T\u7ec6\u80de\u6740\u4f24\u80bf\u7624\u8fc7\u7a0b<\/em><\/span><\/div>\n
\u00a0 \u00a0 \u00a0\u00a0<\/span><\/div>\n<\/div>\n
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CAR-T\u4e5f\u6709\u591a\u79cd\u7c7b\u578b\uff0c\u6839\u636e\u8868\u8fbe\u5171\u6fc0\u5206\u5b50\u7684\u591a\u5c11\uff0c\u53ef\u5c06CAR\u5206\u4e3a\u4e09\u4ee3\uff0c\u5176\u4e2d\u8868\u8fbe\u4e24\u79cd\u5171\u523a\u6fc0\u5206\u5b50\u7684\u7c7b\u578b\u6297\u80bf\u7624\u4f5c\u7528\u663e\u8457\u4f18\u4e8e\u7b2c\u4e00\u4ee3\u4e0d\u8868\u8fbe\u7684\u7c7b\u578b\u3002<\/span><\/div>\n<\/div>\n
\n
CAR-T\u7ec6\u80de\u7597\u6cd5\u89c1\u6548\u5341\u5206\u663e\u8457\uff0c\u5c24\u5176\u662f\u5728\u767d\u8840\u75c5\u8fd9\u6837\u7684\u8840\u6db2\u764c\u75c7\u65b9\u9762\uff0c\u4f46\u4e5f\u6709\u4e0d\u53ef\u5ffd\u89c6\u7684\u526f\u4f5c\u7528 \uff0c\u5982\u5931\u8bed\u3001\u766b\u75eb\u3001\u5fc3\u52a8\u8fc7\u901f\uff0c\u4f4e\u8840\u538b\uff0c\u8f6c\u6c28\u9176\u5347\u9ad8\uff0c\u9ad8\u80c6\u7ea2\u7d20\u8840\u75c7\u7b49\u3002\u6b64\u5916\u5728\u5b9e\u4f53\u7624\u65b9\u9762\uff0c\u56e0\u80bf\u7624\u7ed3\u6784\u81f4\u5bc6\uff0c\u80bf\u7624\u7ec6\u80de\u8868\u8fbe\u514d\u75ab\u6291\u5236\u5206\u5b50\u7b49\u539f\u56e0\uff0cCAR-T\u7ec6\u80de\u6cbb\u7597\u6548\u679c\u88ab\u5f88\u5927\u7a0b\u5ea6\u9650\u5236\u3002\u4f46\u76ee\u524d\u7684\u7814\u7a76\u5df2\u5bf9T\u7ec6\u80de\u8fdb\u884c\u4e86\u8fdb\u4e00\u6b65\u7684\u9057\u4f20\u6539\u9020\uff0c\u589e\u5f3a\u4e86\u5176\u6d78\u6da6\u80fd\u529b\uff0c\u7b2c4\u4ee3CAR-T\u5c06\u6709\u671b\u5bf9\u5b9e\u4f53\u7624\u80bf\u7624\u7ec6\u80de\u8fdb\u884c\u6709\u6548\u6740\u4f24\u3002<\/span><\/div>\n
\u00a0 \u00a0 \u00a0\u00a0<\/span><\/div>\n<\/div>\n
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\u5b9e\u4f53\u7624\u7ed3\u6784\u793a\u610f\u56fe<\/em><\/span><\/div>\n
\u00a0 \u00a0 \u00a0\u00a0<\/span><\/div>\n<\/div>\n
\n
\u76ee\u524d\uff0c\u4e2d\u56fdCAR-T\u7ec6\u80de\u6cbb\u7597\u8fdb\u5165\u98de\u901f\u53d1\u5c55\u9636\u6bb5\uff0c\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u6570\u5df2\u8d85\u8fc7\u5317\u7f8e\uff0c\u5728CAR-T\u7814\u53d1\u5728\u6570\u91cf\u4e0a\u5904\u4e8e\u9886\u5148\u5730\u4f4d\u3002\u5728\u8fd9\u4e9b\u7814\u7a76\u4e2d\uff0c\u6df1\u5927\u603b\u533b\u9662\u8840\u6db2\u79d1CAR-T\u7ec6\u80de\u4e34\u5e8a\u5e94\u7528\uff0c\u5df2\u542f\u52a8\u4e09\u9879CAR-T\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2d\u5bf9\u4e00\u4f8b\u5973\u6027\u6025\u6027\u767d\u8840\u75c5\u7684\u6cbb\u7597\u53d6\u5f97\u4e86\u975e\u5e38\u663e\u8457\u7684\u7597\u6548\u3002\u672a\u6765\uff0cCAR-T\u5c06\u6709\u671b\u5728\u4e34\u5e8a\u4e0a\u53d6\u5f97\u66f4\u591a\u7a81\u7834\uff0c\u9020\u798f\u66f4\u591a\u80bf\u7624\u60a3\u8005\u3002<\/span><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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