{"id":8775,"date":"2022-03-17T10:14:25","date_gmt":"2022-03-17T02:14:25","guid":{"rendered":"https:\/\/clbiomed.com\/?p=8775"},"modified":"2022-04-01T11:07:53","modified_gmt":"2022-04-01T03:07:53","slug":"%e4%b9%90%e5%9c%9f%e5%8a%a9%e5%8a%9b%e4%b8%b4%e5%ba%8a%e5%8f%82%e6%95%b0%e4%b8%8e%e8%82%bf%e7%98%a4%e7%aa%81%e5%8f%98%e8%b4%9f%e8%8d%b7tmb%e7%9b%b8%e5%85%b3%e6%80%a7%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"https:\/\/clbiomed.com\/2022\/03\/%e4%b9%90%e5%9c%9f%e5%8a%a9%e5%8a%9b%e4%b8%b4%e5%ba%8a%e5%8f%82%e6%95%b0%e4%b8%8e%e8%82%bf%e7%98%a4%e7%aa%81%e5%8f%98%e8%b4%9f%e8%8d%b7tmb%e7%9b%b8%e5%85%b3%e6%80%a7%e7%a0%94%e7%a9%b6\/","title":{"rendered":"\u4e50\u571f\u52a9\u529b\u4e34\u5e8a\u53c2\u6570\u4e0e\u80bf\u7624\u7a81\u53d8\u8d1f\u8377TMB\u76f8\u5173\u6027\u7814\u7a76"},"content":{"rendered":"

\u8fd1\u65e5\uff0c\u4e50\u571f\u533b\u5b66\u68c0\u9a8c\u4e0e\u6c5f\u897f\u7701\u80bf\u7624\u533b\u9662\u4e13\u5bb6\u5408\u4f5c\u53d1\u8868\u8bba\u6587\u201cClinical and molecular impacts of tumor mutational burden in histological and cytological specimens from cancer patients\u201d\u4e8eAnnals of Translational Medicine<\/em>\u671f\u520a\u4e0a\uff0c\u4e50\u571f\u4f5c\u4e3a\u5e76\u5217\u901a\u8baf\u548c\u5e76\u5217\u7b2c\u4e00\u4f5c\u8005\u6df1\u5ea6\u53c2\u4e0e\u8be5\u9879\u7814\u7a76\u3002<\/p><\/blockquote>\n

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\u6587\u7ae0\u5bfc\u8bfb<\/strong><\/h4>\n
<\/section>\n<\/section>\n<\/section>\n

\u80bf\u7624\u7a81\u53d8\u8d1f\u8377(TMB)\u662f\u8bc4\u4f30\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242(ICI)\u7597\u6548\u7684\u6709\u6548\u751f\u7269\u6807\u5fd7\u7269\u4e4b\u4e00\uff0c\u7136\u800c\uff0c\u5b83\u4e0e\u4e34\u5e8a\u53c2\u6570\u95f4\u7684\u5173\u7cfb\u5c1a\u672a\u88ab\u5145\u5206\u63a2\u8ba8\u3002\u4e50\u571f\u533b\u5b66\u68c0\u9a8c\u4e0e\u6c5f\u897f\u7701\u80bf\u7624\u533b\u9662\u5408\u4f5c\uff0c\u901a\u8fc7\u6d4b\u5e8f\u5206\u67901504\u4f8b\u80bf\u7624\u7ec4\u7ec7\u6837\u672c\u548c496\u4f8b\u8840\u6db2\u6837\u672c\u6765\u63a2\u8ba8TMB\u4e0e\u5e74\u9f84\u3001\u80bf\u7624\u7c7b\u578b\u548c\u57fa\u56e0\u7a81\u53d8\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/p>\n

<\/section>\n
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\u7814\u7a76\u53d1\u73b0<\/strong><\/h4>\n
<\/section>\n<\/section>\n<\/section>\n

1\uff09\u5bf9\u4e8e\u8840\u6db2\u6837\u672c\uff0c\u4e0e\u5e74\u9f84\u226456\u5c81\u6216\u5e74\u9f84\u572856\u5c81~68\u5c81\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u5e74\u9f84\u226568\u5c81\u7684\u60a3\u8005TMB\u660e\u663e\u5347\u9ad8\u3002\u643a\u5e26KRAS p.G12\u7a81\u53d8\u4e0eKRAS\u5176\u4ed6\u53d8\u5f02\u60a3\u8005\u7684TMB\u5177\u6709\u663e\u8457\u5dee\u5f02\u3002<\/p>\n

2\uff09\u5bf9\u4e8e\u7ec4\u7ec7\u6837\u672c\uff0cTMB\u5728\u5e74\u9f8453\u5c81~65\u5c81\u4e4b\u95f4\u8868\u8fbe\u8f83\u9ad8\uff0c\u5728\u5e74\u9f84\u226565\u5c81\u4eba\u7fa4\u4e2d\u8f83\u4f4e\u3002TMB\u5728\u80ba\u817a\u9cde\u764c(ASC)\u3001\u80ba\u817a\u764c(LUAD)\u3001\u80ba\u9cde\u72b6\u7ec6\u80de\u764c(LUSC)\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC)\u548c\u5c0f\u7ec6\u80de\u80ba\u764c(SCLC)\u7b49\u4e0d\u540c\u7684\u80bf\u7624\u7ec4\u7ec7\u7c7b\u578b\u95f4\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002TMB\u9ad8\u4f4e\u4e0eKRAS p.G12A\u3001p.G12C\u3001p.G12D\u3001p.G12R\u3001p.G12S\u3001p.G12V\u7b49KRAS\u7a81\u53d8\u76f8\u5173\u3002<\/p>\n

\n
\n
3\uff09\u65e0\u8bba\u5728\u7ec4\u7ec7\u6837\u672c\u8fd8\u662f\u8840\u6db2\u6837\u672c\u4e2d\uff0cTMB\u548cMSI\u503c\u65e0\u7ebf\u6027\u76f8\u5173\u3002<\/section>\n<\/section>\n<\/section>\n
\n
\n
<\/section>\n<\/section>\n
\n
\n

\u603b\u7ed3<\/strong><\/h4>\n
<\/section>\n<\/section>\n<\/section>\n

TMB\u53ef\u80fd\u4e0e\u5e74\u9f84\u3001\u80bf\u7624\u7c7b\u578b\u4ee5\u53caKRAS\u7a81\u53d8\u76f8\u5173\u3002\u4f5c\u4e3a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u4e00\u4e2a\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5206\u6790\u5e74\u9f84\u3001\u80bf\u7624\u7c7b\u578b\u548cKRAS\u7a81\u53d8\u53ef\u80fd\u4e3aTMB\u7684\u8bc4\u4f30\u63d0\u4f9b\u66f4\u6709\u76ca\u7684\u5e2e\u52a9\u3002<\/p>\n<\/section>\n

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\n
<\/section>\n
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\u6587\u7ae0\u5177\u4f53\u89e3\u8bfb<\/strong><\/h3>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n
<\/section>\n
\n
\u65b9\u6cd5<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u7814\u7a76\u5171\u7eb3\u5165\u4e862019\u52302021\u5e74\u95f4\u4e50\u571f\u4e0e\u6c5f\u897f\u7701\u80bf\u7624\u533b\u9662\u5408\u4f5c\u68c0\u6d4b\u7684496\u4f8b\u8840\u6db2\u548c1504\u4f8b\u80bf\u7624\u7ec4\u7ec7\u6837\u672c\uff0c\u901a\u8fc7\u57fa\u56e0\u68c0\u6d4b\u53ca\u7edf\u8ba1\u5b66\u5206\u6790\u63a2\u8ba8TMB\u4e0e\u4e34\u5e8a\u6837\u672c\u5e74\u9f84\u3001\u80bf\u7624\u7c7b\u578b\u548c\u57fa\u56e0\u7a81\u53d8\uff08KRAS\u548cEGFR\uff09\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/p>\n

\u6587\u7ae0\u6240\u6709\u7814\u7a76\u5747\u7b26\u5408\u8d6b\u5c14\u8f9b\u57fa\u5ba3\u8a00\uff082013\u5e74\u4fee\u8ba2\uff09\uff0c\u5e76\u901a\u8fc7\u4e86\u6c5f\u897f\u7701\u80bf\u7624\u533b\u9662\u4f26\u7406\u59d4\u5458\u4f1a\u6279\u51c6\uff08\u7f16\u53f7\uff1a2021ky229\uff09\uff0c\u6240\u6709\u60a3\u8005\u5747\u7b7e\u7f72\u4e86\u77e5\u60c5\u540c\u610f\u4e66\u3002<\/p>\n

\n
\n
\n
<\/section>\n
\n
\u5206\u6790\u7ed3\u679c\/\u6837\u672c\u7279\u5f81<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u7814\u7a76\u5171\u7eb3\u5165496\u4f8b\u8840\u6db2\u6837\u672c\u548c1504\u4f8b\u7ec4\u7ec7\u6837\u672c\uff0c\u8840\u6db2\u6837\u672c\u7684\u5e74\u9f84\u8303\u56f4\u4e3a\uff0861.58 \u00b112.48\uff09\u5c81\uff0c\u7537:\u5973=314:182\uff1b\u7ec4\u7ec7\u6837\u672c\u7684\u5e74\u9f84\u8303\u56f4\u4e3a\uff0857.42\u00b114.67\uff09\u5c81\uff0c\u7537:\u5973=866:638\u3002\u6837\u672c\u7684\u5177\u4f53\u4fe1\u606f\u89c1\u88681\u3002<\/p>\n

Table 1 Characteristics of blood samples and tissue samples<\/p>\n

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 <\/p>\n

\n
\n
\n
<\/section>\n
\n
TMB\u4e0e\u5e74\u9f84\u3001\u80bf\u7624\u7c7b\u578b\u53ca\u57fa\u56e0\u7a81\u53d8\u7684\u5173\u7cfb<\/strong><\/h5>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u5728496\u4f8b\u8840\u6db2\u6837\u672c\u4e2d\uff0cTMB\u503c\u5728\u5e74\u9f84\u226456\u5c81\u548c\u5e74\u9f84\u572856\u5c81\u523068\u5c81\u4e4b\u95f4\u7684\u4eba\u7fa4\u4e2d\u6ca1\u6709\u663e\u8457\u5dee\u5f02\uff0c\u800c\u5728\u5e74\u9f84\u226568\u5c81\u7684\u4eba\u7fa4\u4e2d\u663e\u8457\u5347\u9ad8\uff08\u56fe1A\uff0cP<0.05\uff0cKruskal-Wallis\uff09\u3002\u5176\u4e2d12\u4f8b\u4e3aMSI-H\uff0c484\u4f8b\u4e3aMSS\/MSI-L\uff08\u56fe1B\uff09\u3002\u5982\u56fe1C\u6240\u793a\uff0c\u5206\u6790\u7ed3\u679c\u8868\u660eMSI\u7684\u6bd4\u503c\uff08%\uff09\u4e0eTMB\u6ca1\u6709\u7ebf\u6027\u76f8\u5173\u6027\uff08R=\u22120.093, P=0.038\uff09\u3002<\/p>\n

\u901a\u8fc7\u8bc4\u4f30\u80bf\u7624\u7c7b\u578b\u548cTMB\u7684\u5173\u7cfb\u53d1\u73b0\uff0cTMB\u548c\u80bf\u7624\u7c7b\u578b\u65e0\u5173\uff0c\u5728\u80ba\u817a\u9cde\u764c\u3001\u80ba\u817a\u764c\u3001\u80ba\u9cde\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2dTMB\u65e0\u5dee\u5f02\uff08\u56fe1D\uff0cP=0.33, Kruskal-Wallis\uff09\u3002<\/p>\n

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\u56fe1-\u8840\u6db2\u6837\u672c\u4e2dTMB\u4e0e\u5e74\u9f84\u3001MSI\u6216\u80bf\u7624\u7c7b\u578b\u4e4b\u95f4\u7684\u5173\u7cfb<\/p><\/div>\n

A.\u00a0<\/strong>TMB\u5728\u5e74\u9f84\u226456\u5c81\uff08n=157\uff09\uff0c\u5e74\u9f8456-68\u5c81\uff08n=177\uff09\u548c\u5e74\u9f84\u226568\u5c81\uff08n=161\uff09\u4e4b\u95f4\u7684\u8868\u8fbe\u5dee\u5f02\u3002<\/p>\n

B&C.\u00a0<\/strong>MSI-H\uff08n=12\uff09\u548cMSS\/MSI-L\uff08n=484\uff09\u7684\u60c5\u51b5\u53ca\u8840\u6db2\u6837\u672c\u4e2dMSI\u6bd4\u503c\u4e0eTMB\u7684\u5173\u7cfb\u3002<\/p>\n

D.\u00a0<\/strong>\u80ba\u817a\u9cde\u764c\uff08n=0\uff09\u3001\u80ba\u817a\u764c\uff08n=131\uff09\u3001\u80ba\u9cde\u764c\uff08n=7\uff09\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08n=3\uff09\u548c\u5c0f\u7ec6\u80de\u80ba\u764c\uff08n=3\uff09\u6837\u672c\u4e2d\u7684TMB\u60c5\u51b5\u3002<\/p>\n

\u57281390\u4f8b\u7ec4\u7ec7\u6837\u672c\u4e2d\uff0c\u5982\u56fe2\u6240\u793a\uff0c\u4e0e\u5e74\u9f84\u226453\u5c81\u4eba\u7fa4\u76f8\u6bd4\uff0cTMB\u503c\u5728\u5e74\u9f84\u226565\u5c81\u548c\u5e74\u9f84\u572853\u5c81\u523065\u5c81\u4e4b\u95f4\u7684\u4eba\u7fa4\u4e2d\u6ca1\u6709\u663e\u8457\u5dee\u5f02\uff0c\u572853\u5c81\u523065\u5c81\u4eba\u7fa4\u4e2dTMB\u663e\u8457\u5347\u9ad8\uff0c\u5728\u226565\u5c81\u4eba\u7fa4\u4e2dTMB\u663e\u8457\u964d\u4f4e\uff08\u56fe2A\uff0cP<0.05, Kruskal-Wallis\uff09\u3002\u5176\u4e2d33\u4f8b\u4e3aMSI-H\uff0c1357\u4f8b\u4e3aMSS\/MSI-L\uff08\u56fe2B\uff09\u3002\u5982\u56fe2C\u6240\u793a\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8868\u660eMSI\u7684\u6bd4\u503c\uff08%\uff09\u4e0eTMB\u6ca1\u6709\u7ebf\u6027\u76f8\u5173\u6027\uff08R=0.29, P<2.2e-16\uff09\u3002<\/p>\n

\u901a\u8fc7\u8bc4\u4f30\u80bf\u7624\u7c7b\u578b\u548cTMB\u7684\u5173\u7cfb\u53d1\u73b0\uff0cTMB\u4e0e\u80bf\u7624\u7c7b\u578b\u76f8\u5173\uff08\u56fe2D, P=0.037, Kruskal-Wallis\uff09\uff0c\u5728\u80ba\u817a\u9cde\u764c\u3001\u80ba\u817a\u764c\u3001\u80ba\u9cde\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u5c0f\u7ec6\u80de\u80ba\u764c\u95f4\u5b58\u5728\u5dee\u5f02\u3002\u800c\u4e14TMB\u5728\u7ed3\u76f4\u80a0\u764c\u7684\u8840\u6db2\u6837\u672c\u548c\u7ec4\u7ec7\u6837\u672c\u4e2d\u5747\u5b58\u5728\u5dee\u5f02\uff08\u56fe2E\uff0cP=0.036, Wilcoxon\uff09\u3002<\/p>\n

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\u56fe2-\u7ec4\u7ec7\u6837\u672c\u4e2dTMB\u4e0e\u5e74\u9f84\u3001MSI\u6216\u80bf\u7624\u7c7b\u578b\u4e4b\u95f4\u7684\u5173\u7cfb<\/p><\/div>\n

A.\u00a0<\/strong>TMB\u5728\u5e74\u9f84\u226453\u5c81\uff08n=489\uff09\uff0c\u5e74\u9f8453-65\u5c81\uff08n=497\uff09\u548c\u5e74\u9f84\u226565\u5c81\uff08n=512\uff09\u4e4b\u95f4\u7684\u8868\u8fbe\u5dee\u5f02\u3002<\/p>\n

B&C.\u00a0<\/strong>MSI-H\uff08n=33\uff09\u548cMSS\/MSI-L\uff08n=1357\uff09\u7684\u60c5\u51b5\u53ca\u7ec4\u7ec7\u6837\u672c\u4e2dMSI\u6bd4\u503c\u4e0eTMB\u7684\u5173\u7cfb\u3002<\/p>\n

D.\u00a0<\/strong>\u80ba\u817a\u9cde\u764c\uff08n=1\uff09\u3001\u80ba\u817a\u764c\uff08n=222\uff09\u3001\u80ba\u9cde\u764c\uff08n=26\uff09\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08n=3\uff09\u548c\u5c0f\u7ec6\u80de\u80ba\u764c\uff08n=8\uff09\u6837\u672c\u4e2dTMB\u8868\u8fbe\u60c5\u51b5\u3002<\/p>\n

E. TMB\u5728\u7ed3\u76f4\u80a0\u764c\u8840\u6db2\u6837\u672c\uff08n=4\uff09\u548c\u7ec4\u7ec7\u6837\u672c\uff08n=20\uff09\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5\u3002<\/p>\n

\u57fa\u56e0\u7a81\u53d8\u72b6\u6001\u4e0eTMB\u76f8\u5173\u3002\u65e2\u5f80\u90e8\u5206\u7814\u7a76\u8868\u660e\uff0c\u643a\u5e26EGFR\u57fa\u56e0\u7a81\u53d8\u7684NSCLC\u60a3\u8005\u5f80\u5f80\u5177\u6709\u8f83\u4f4e\u7684TMB\uff0c\u800cKRAS\u4e0e\u8f83\u9ad8\u7684TMB\u76f8\u5173\u3002<\/p>\n

\u5728\u6211\u4eec\u7684\u7814\u7a76\u4e2d\uff0c\u8840\u6db2\u6837\u672c\u4e2d\u7684Kruskal-Wallis\u5206\u6790\u7ed3\u679c\u8868\u660e\uff0cKRAS p.G12A\u3001p.G12C\u3001p.G12D\u3001p.G12R\u3001p.G12V\u548cKRAS\u5176\u4ed6\u7a81\u53d8\u4e4b\u95f4\u7684TMB\u6ca1\u6709\u663e\u8457\u5dee\u5f02\uff08P=0.17\uff09\uff08\u56fe3A\uff0cP=0.17, Kruskal-Wallis\uff09\uff0c\u4f46\u6839\u636eWilcoxon \u68c0\u9a8c\uff0cKRAS\u5176\u4ed6\u7a81\u53d8\u548cKRAS p.G12\u7a81\u53d8\u4e4b\u95f4\u7684TMB\u8868\u8fbe\u5b58\u5728\u663e\u8457\u5dee\u5f02\uff08P=0.013\uff0c\u56fe3B\uff09\u3002<\/p>\n

\u901a\u8fc7\u8bc4\u4f30EGFR\u7a81\u53d8\u4e0eTMB\u7684\u5173\u7cfb\uff0c\u53d1\u73b0EGFR\u7a81\u53d8\u9634\u6027\u60a3\u8005\uff08n=484\uff09\u4e0eEGFR\u7a81\u53d8\u9633\u6027\u60a3\u8005\uff08n=12\uff09\u7684TMB\u65e0\u663e\u8457\u6027\u5dee\u5f02\uff08\u56fe3C\uff0cP=0.11\uff0cWilcoxon\uff09\uff0cEGFR T790M\u7a81\u53d8\u9634\u6027\u548c\u9633\u6027\u60a3\u8005\u4e4b\u95f4\u7684TMB\u4e5f\u4e0d\u5b58\u5728\u7edf\u8ba1\u5b66\u5dee\u5f02\uff08\u56fe 3D\uff09\u3002<\/section>\n
\"\"

\u56fe3-\u8840\u6db2\u6837\u672c\u4e2dTMB\u548c\u764c\u75c7\u76f8\u5173\u57fa\u56e0\u7a81\u53d8\u7684\u5173\u7cfb<\/p><\/div>\n

\n
\n
A.\u00a0<\/strong>TMB\u5728KRAS p.G12A (n=1), p.G12C (n=3), p.G12D (n=9), p.G12R (n=5), p.G12V (n=11),\u548cKRAS\u5176\u4ed6\u7a81\u53d8 (n=467)\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5\u3002<\/section>\n
B.\u00a0<\/strong>TMB\u5728KRAS\u5176\u4ed6\u7a81\u53d8\uff08n=467\uff09\u548cKRAS p.G12\uff08n=29\uff09\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5\u3002<\/section>\n
C.\u00a0<\/strong>TMB\u5728EGFR\u7a81\u53d8\u9634\u6027\u60a3\u8005 (n=484)\u548c\u7a81\u53d8\u9633\u6027\u60a3\u8005 (n=12)\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5\u3002<\/section>\n
D.\u00a0<\/strong>TMB\u5728EGFR T790M\u7a81\u53d8\u9634\u6027\u548c\u7a81\u53d8\u9633\u6027\u60a3\u8005\u4e4b\u95f4\u7684\u8868\u8fbe\u60c5\u51b5\u3002<\/section>\n<\/section>\n<\/section>\n
\u5728\u7ec4\u7ec7\u6837\u672c\u4e2d\uff0cKRAS p.G12A\u3001p.G12C\u3001p.G12D\u3001p.G12R\u3001p.G12S\u3001p.G12V\u548c KRAS\u5176\u4ed6\u7a81\u53d8\u7684TMB\u5b58\u5728\u663e\u8457\u6027\u5dee\u5f02\uff08\u56fe4A\uff0cP=0.033\uff0cKruskal-Wallis)\uff0cKRAS\u5176\u4ed6\u7a81\u53d8\u548cKRAS p.G12\u7a81\u53d8\u4e4b\u95f4\u7684TMB\u4e5f\u5b58\u5728\u663e\u8457\u6027\u5dee\u5f02\uff08\u56fe4C\uff0cP=0.0051\uff0cWilcoxon\uff09\u3002\u4f46EGFR\u7a81\u53d8\u9634\u6027\u60a3\u8005\u548cEGFR\u7a81\u53d8\u9633\u6027\u60a3\u8005\u4e0eTMB\u672a\u53d1\u73b0\u76f8\u5173\u6027\uff08\u56fe4D\uff0cP=0.59\uff0cWilcoxon\uff09\u3002<\/section>\n
\"\"<\/section>\n

 <\/p>\n

\n
\u56fe4-\u7ec4\u7ec7\u6837\u672c\u4e2dTMB\u548c\u764c\u75c7\u76f8\u5173\u57fa\u56e0\u7a81\u53d8\u7684\u5173\u7cfb<\/strong><\/section>\n<\/section>\n
\n
\n
A&B.\u00a0<\/strong>TMB\u5728KRAS p.G12A (n=7), p.G12C (n=13), p.G12D (n=81), p.G12R(n=6), p.G12S(n=8), p.G12V(n=56), \u548cKRAS\u5176\u4ed6\u7a81\u53d8(n=1333)\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5\u3002<\/p>\n

C.\u00a0<\/strong>TMB\u5728KRAS\u5176\u4ed6\u7a81\u53d8\uff08n=1333\uff09\u548cKRAS p.G12\uff08n=171\uff09\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5\u3002<\/p>\n

\n
\n
\n
\n
\n
\n
D.\u00a0<\/strong>TMB\u5728EGFR\u7a81\u53d8\u9634\u6027\u60a3\u8005 (n=1497) \u548c EGFR\u7a81\u53d8\u9633\u6027\u60a3\u8005 (n=7)\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

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