{"id":9353,"date":"2022-06-09T12:15:16","date_gmt":"2022-06-09T04:15:16","guid":{"rendered":"https:\/\/clbiomed.com\/?p=9353"},"modified":"2022-06-09T12:15:16","modified_gmt":"2022-06-09T04:15:16","slug":"%e9%87%8d%e7%a3%85-%e6%9c%89%e6%9c%9b%e6%b6%88%e7%81%ad%e7%99%8c%e7%97%87%ef%bc%81%e3%80%8a%e8%87%aa%e7%84%b6%e3%80%8b%e5%b8%a6%e6%9d%a5%e5%85%a8%e6%96%b0%e8%ae%be%e8%ae%a1%e7%99%8c%e7%97%87","status":"publish","type":"post","link":"https:\/\/clbiomed.com\/2022\/06\/%e9%87%8d%e7%a3%85-%e6%9c%89%e6%9c%9b%e6%b6%88%e7%81%ad%e7%99%8c%e7%97%87%ef%bc%81%e3%80%8a%e8%87%aa%e7%84%b6%e3%80%8b%e5%b8%a6%e6%9d%a5%e5%85%a8%e6%96%b0%e8%ae%be%e8%ae%a1%e7%99%8c%e7%97%87\/","title":{"rendered":"\u91cd\u78c5 | \u6709\u671b\u6d88\u706d\u764c\u75c7\uff01\u300a\u81ea\u7136\u300b\u5e26\u6765\u5168\u65b0\u8bbe\u8ba1\u764c\u75c7\u75ab\u82d7"},"content":{"rendered":"

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\"\"

\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u53d1\u8868\u4e86\u4e00\u7bc7\u9898\u4e3a” A vaccine targeting resistant tumours by dual T cell plus NK cell attack “\u7684\u7814\u7a76\u8bba\u6587\u3002<\/p><\/div>\n

\u764c\u75c7\u662f\u5a01\u80c1\u4eba\u7c7b\u5065\u5eb7\u7684\u5934\u53f7\u6740\u624b\u3002\u4eba\u4eec\u8c08\u201c\u764c\u201d\u8272\u53d8\uff0c\u4e3b\u8981\u6e90\u4e8e\u764c\u75c7\u7684\u6cbb\u7597\u5c40\u9650\uff0c\u4e34\u5e8a\u4e0a\u81f3\u4eca\u65e0\u6cd5\u5f7b\u5e95\u653b\u514b\u764c\u75c7\uff0c\u764c\u75c7\u7684\u6b7b\u4ea1\u7387\u5c45\u9ad8\u4e0d\u4e0b\u3002\u8fd1\u5e74\u6765\uff0c\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u6280\u672f\u7684\u4e0d\u65ad\u7a81\u7834\uff0c\u4ee5\u201c\u5524\u9192\u4eba\u4f53\u9488\u5bf9\u764c\u75c7\u7684\u514d\u75ab\u7cfb\u7edf\u201d\u4e3a\u57fa\u7840\u539f\u7406\u7684\u764c\u75c7\u75ab\u82d7\u5907\u53d7\u79d1\u5b66\u5bb6\u7684\u5173\u6ce8\uff0c\u8fd9\u610f\u5473\u7740\u4eba\u7c7b\u6297\u764c\u6218\u4e89\u5373\u5c06\u8fdb\u5165\u4e00\u4e2a\u65b0\u9636\u6bb5\u3002<\/p>\n

\u764c\u75c7\u75ab\u82d7\u5c0f\u79d1\u666e\uff1a<\/strong><\/span><\/p>\n

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\"\"

\u6297\u4f53\u6e32\u67d3\u56fe<\/p><\/div>\n

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\u800c\u300a\u81ea\u7136\u300b\u5e26\u6765\u7684\u5168\u65b0\u8bbe\u8ba1\u764c\u75c7\u75ab\u82d7\uff0c\u6709\u671b\u4e00\u4e3e\u89e3\u51b3\u4ee5\u4e0a\u96be\u9898\u3002\u8fd9\u662f\u4e00\u79cd\u9488\u5bf9\u80bf\u7624\u514d\u75ab\u9003\u9038\u673a\u5236\u7684\u6982\u5ff5\u6027\u65b0\u764c\u75c7\u75ab\u82d7\uff0c\u8be5\u75ab\u82d7\u9488\u5bf9MICA\u548cMICB\uff08MICA\/B\uff09\u4e24\u7c7b\u8868\u9762\u86cb\u767d\u9776\u70b9\uff0c\u8bf1\u5bfc\u4e0d\u540c\u7684T\u7ec6\u80de\u548c\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\u8fdb\u884c\u534f\u540c\u653b\u51fb\uff0c\u5e2e\u52a9\u514d\u75ab\u7cfb\u7edf\u6d88\u9664\u80bf\u7624\u9632\u5fa1\u7cfb\u7edf\u6765\u6467\u6bc1\u764c\u75c7\u3002<\/p>\n

    \n
  • \u5e7f\u8c31\u6027\u9776\u70b9\uff0c\u89e3\u51b3\u80bf\u7624\u6297\u539f\u4e2a\u6027\u5316\u5dee\u5f02<\/strong><\/li>\n<\/ul>\n

    \u56e0DNA\u635f\u4f24\u800c\u5e7f\u6cdb\u8868\u8fbe\u4e8e\u591a\u79cd\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684\u80bf\u7624\u7279\u5f02\u6027\u6297\u539fMICA\/B\uff0c\u5e76\u4e14\u5728\u5065\u5eb7\u7ec6\u80de\u4e2d\u51e0\u4e4e\u68c0\u6d4b\u4e0d\u5230\u3002\u56e0\u6b64\uff0c\u501f\u52a9\u591a\u79cd\u80bf\u7624\u7ec6\u80de\u8868\u8fbeMICA\/B\u7684\u7279\u70b9\uff0c\u65e0\u9700\u7ed9\u6bcf\u4e2a\u60a3\u8005\u5b9a\u5236\u4e2a\u6027\u5316\u75ab\u82d7\u3002<\/p>\n

    MICA\/B\u80fd\u591f\u6210\u4e3a\u6fc0\u6d3bT\u7ec6\u80de\u548c\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\u7684\u914d\u4f53\uff0c\u52a0\u901f\u514d\u75ab\u7cfb\u7edf\u6d88\u706d\u764c\u75c7\u3002\u8fd9\u662f\u56e0\u4e3a\u4e00\u65b9\u9762\uff0cMICA\/B\u53ef\u7531\u6297\u539f\u9012\u5448\u7ec6\u80de\uff08\u6811\u7a81\u72b6\u7ec6\u80de\u7b49\uff09\u5448\u9012\u7ed9CD4+T\u7ec6\u80de\uff0c\u8fdb\u800c\u4ecb\u5bfc\u80bf\u7624\u6740\u4f24\u4f5c\u7528\uff1b\u53e6\u4e00\u65b9\u9762MICA\/B\u53ef\u4e0eCD8+T\u7ec6\u80de\u548cNK\u7ec6\u80de\u8868\u9762\u7684NKG2D\u53d7\u4f53\u7ed3\u5408\uff0c\u6fc0\u6d3bCD8+T\u7ec6\u80de\u548cNK\u7ec6\u80de\u7684\u80bf\u7624\u6740\u4f24\u4f5c\u7528\u3002<\/p>\n

      \n
    • \u9632\u6b62\u80bf\u7624\u6297\u539f\u7a81\u53d8\uff0c\u9003\u9038\u514d\u75ab\u76d1\u63a7<\/strong><\/li>\n<\/ul>\n

      \u4e0d\u8fc7\u80bf\u7624\u7ec6\u80de\u5e76\u4e0d\u4f1a\u653e\u4efb\u8fd9\u4e00\u5bf9\u81ea\u5df1\u6709\u5a01\u80c1\u7684\u4e8b\u60c5\u53d1\u751f\uff0c\u5b83\u4eec\u4f1a\u901a\u8fc7\u86cb\u767d\u6c34\u89e3\u8fc7\u7a0b\u5bf9MICA\/B\u8fdb\u884c\u5206\u89e3\u5207\u5272\uff0c\u51cf\u5c11\u5b83\u4eec\u6fc0\u6d3b\u514d\u75ab\u7ec6\u80de\u7684\u53ef\u80fd\u6027\uff1b\u540c\u65f6\uff0cMICA\/B\u8131\u843d\u8fd8\u53ef\u8bf1\u5bfcNKG2D\u53d7\u4f53\u5185\u5316\u800c\u6291\u5236NK\u7ec6\u80de\u529f\u80fd\uff0c\u4ece\u800c\u9003\u907f\u514d\u75ab\u653b\u51fb\u3002<\/p>\n

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      \u76ee\u524d\uff0c\u7814\u7a76\u4eba\u5458\u5df2\u6210\u529f\u8fdb\u884c\u4e86\u52a8\u7269\u8bd5\u9a8c\u5e76\u9a8c\u8bc1\u4e86\u5176\u5b89\u5168\u6027\u3002\u4ed6\u4eec\u53d1\u73b0\u5728\u80bf\u7624\u5c0f\u9f20\u4e2d\u4f7f\u7528\u75ab\u82d7\u53ef\u4ee5\u663e\u8457\u51cf\u5c11\u80bf\u7624\u7684\u8f6c\u79fb\uff0c\u964d\u4f4e\u764c\u7ec6\u80de\u7684\u751f\u957f\u901f\u5ea6\uff0c\u8fd9\u4e9b\u521d\u6b65\u7ed3\u679c\u663e\u793a\uff0c\u57fa\u4e8eMICA\/B\u7684\u764c\u75c7\u75ab\u82d7\u53ef\u4ee5\u6fc0\u6d3b\u6709\u6548\u7684\u80bf\u7624\u514d\u75ab\u3002\u4ed6\u4eec\u73b0\u5728\u6b63\u5728\u8bbe\u8ba1\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5c06\u5728\u4eba\u4f53\u4e2d\u6d4b\u8bd5\u8fd9\u79cd\u65b0\u75ab\u82d7\u3002<\/p>\n

      \"\"<\/p>\n

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